A clinical risk score to identify patients at high risk of very late stent thrombosis

Journal of Interventional Cardiology
Thea C GodschalkJurriën M Ten Berg

Abstract

The aim of this study was to determine predictors of very late stent thrombosis (VLST; >1 year after stenting), and to evaluate whether addition of these predictors to the dual antiplatelet therapy (DAPT) score would improve the ability to identify patients at high risk of VLST who might benefit from DAPT. VLST is a severe complication of percutaneous coronary intervention (PCI). Extended knowledge about the predictors of VLST is needed to prevent this life-threatening complication. Recent data showed a reduction in VLST after treatment with prolonged DAPT. The DAPT study developed a prediction score to identify patients after PCI who might benefit from prolonged DAPT duration. The Dutch stent thrombosis study is a multi-center case-control study. Consecutive patients with definite VLST were included between 2007 and 2014. Baseline characteristics from the index PCI were collected. Independent predictors of VLST were identified and added to the DAPT score to develop the VLST score. In total, 155 VLST cases and 155 matched controls were included. Suboptimal result of stenting, right coronary artery as target vessel, and diffuse coronary artery ectasia were independent predictors of VLST, and added to the DAPT score. The power of...Continue Reading

References

May 21, 2003·Annals of Internal Medicine·James M BrophyLawrence Joseph
May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
May 19, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Aloke V FinnRenu Virmani
Apr 18, 2009·Journal of the American College of Cardiology·Jochem W van WerkumJurriën M ten Berg
Feb 19, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Kenneth W BaranUNKNOWN ARRIVE Investigators
Apr 25, 2012·Archives of Internal Medicine·Giuseppe De LucaUNKNOWN Drug-Eluting Stent in Primary Angioplasty (DESERT) Cooperation
May 21, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Javaid IqbalJulian Gunn
Nov 6, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Shunsuke KuboKazuaki Mitsudo
Feb 21, 2014·Atherosclerosis·Natale Daniele BrunettiMatteo Di Biase
Jul 7, 2014·Journal of the American College of Cardiology·Giovanna SarnoStefan K James
Nov 18, 2014·The New England Journal of Medicine·Laura MauriUNKNOWN DAPT Study Investigators
Mar 17, 2015·The New England Journal of Medicine·Marc P BonacaUNKNOWN PEGASUS-TIMI 54 Steering Committee and Investigators
Apr 18, 2015·Journal of cardiology·Li XuXinchun Yang
Feb 27, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Femi PhilipJeffrey A Southard
Mar 30, 2016·JAMA : the Journal of the American Medical Association·Robert W YehUNKNOWN DAPT Study Investigators
Aug 31, 2016·The New England Journal of Medicine·Kaare H BønaaUNKNOWN NORSTENT Investigators
May 23, 2017·Frontiers in Cardiovascular Medicine·Sara Abou SherifIsmail Dogu Kilic

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Citations

Jun 21, 2020·International Journal of Clinical Practice·Chun Shing KwokMamas A Mamas
Jan 7, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Yusuke WatanabeUNKNOWN REAL-ST Registry Investigators
Apr 6, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Minkwan KimHyo-Soo Kim

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