PMID: 9527139Apr 4, 1998Paper

A clinical role for 99mTc-HMPAO SPECT in the investigation of dementia?

Journal of Neurology, Neurosurgery, and Psychiatry
P R TalbotH J Testa

Abstract

To provide the clinician with a guide to the clinical utility of 99mTc-HMPAO single photon emission computed tomography (SPECT) and to the interpretation of specific test results in the differential diagnosis of dementia. Three hundred and sixty three patients with dementia were studied prospectively for a median three (range 1-6) years and classified into disease groups on the basis of established clinical criteria. The degree to which different patterns of cerebral blood flow (CBF) abnormality found on 99mTc-HMPAO SPECT imaging at the time of initial patient presentation modified clinical diagnoses was determined by calculating the likelihood ratios for pairwise disease group comparisons. The optimal clinical usage of 99mTc-HMPAO SPECT was determined by calculating the percentage of significant test results for each pairwise disease group comparison. Bilateral posterior CBF abnormality was found to significantly increase the odds of a patient having Alzheimer's disease as opposed to vascular dementia or frontotemporal dementia. Bilateral anterior CBF abnormality significantly increased the odds of a patient having frontotemporal dementia as opposed to Alzheimer's disease, vascular dementia, or Lewy body disease. "Patchy" CBF ...Continue Reading

References

Nov 1, 1992·Psychological Medicine·I G McKeithE K Perry
Jul 11, 1992·Archives of Neurology·R J Caselli, C R Jack
Feb 1, 1992·Annals of Neurology·J S SnowdenH J Testa
Jan 1, 1992·European Journal of Nuclear Medicine·K KourisP J Ell
Jan 1, 1991·European Journal of Nuclear Medicine·M O HabertS Askienazy
Sep 1, 1990·Journal of Neuroscience Methods·P J Ell
Jan 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·D MontaldiJ McCulloch
Feb 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·D NearyA N Davison
Feb 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·A BurnsR Levy
Mar 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·D NearyP Goulding
Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S C SarisR G Blasberg
Jan 1, 1988·Journal of Clinical Epidemiology·N J Birkett
Sep 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·D NearyH J Testa
Dec 1, 1986·AJR. American Journal of Roentgenology·W C Black, P Armstrong
Jun 1, 1995·Nuclear Medicine Communications·P R Talbot, H J Testa
Oct 1, 1994·European Journal of Nuclear Medicine·R Kerwin
Jul 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·S E StarksteinR Leiguarda
Oct 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·D NearyD M Mann
Jan 1, 1993·Acta Neuropathologica·D M Mann, P W South

❮ Previous
Next ❯

Citations

Dec 1, 2006·Der Radiologe·F StreitparthN Hidajat
Oct 3, 2001·Current Treatment Options in Neurology·Theresa A. ZesiewiczRobert A. Hauser
Oct 19, 2007·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Cheryl L StopfordDavid Neary
Nov 15, 2000·Disease-a-month : DM·C DeCarli
Mar 23, 2000·Journal of the Neurological Sciences·T Fukui, A Kertesz
Nov 6, 2002·Journal of the Neurological Sciences·Wanda LojkowskaIzabela Kozlowicz-Gudzinska
Feb 20, 2003·Neuropsychologia·J S SnowdenD Neary
Aug 17, 2002·Neuroscience Letters·Giovanni PennisiRita Bella
May 26, 2001·Clinics in Geriatric Medicine·C DeCarli
Jul 7, 2011·International Psychogeriatrics·Karl Herholz
May 1, 2009·Journal of the International Neuropsychological Society : JINS·John ListerudMurray Grossman
Oct 10, 2008·Seminars in Neurology·Paolo VitaliMichael D Geschwind
Jul 26, 2005·Topics in Magnetic Resonance Imaging : TMRI·António J Bastos LeiteFrederik Barkhof
May 18, 2010·Alzheimer Disease and Associated Disorders·Lejla KoricMathieu Ceccaldi
Jun 21, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·J C ThompsonD Neary
Dec 13, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·R McNeillA R Varma
Jul 16, 2005·Dementia and Geriatric Cognitive Disorders·F MaestúA Portera
Aug 2, 2003·Applied Neuropsychology·Robert PaulRonald Cohen
Apr 1, 2006·Biomedical Imaging and Intervention Journal·N RamliCt Tan
Sep 26, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Ingeborg GoethalsRudi Dierckx
Feb 4, 2003·Radiology·Jeffrey R PetrellaP Murali Doraiswamy
May 26, 2001·Clinics in Geriatric Medicine·D S Knopman
Dec 18, 2013·Seminars in Roentgenology·David Clopton, Thomas Jason Druzgal
Jan 18, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Cheryl L StopfordJulie S Snowden
Oct 9, 2003·Mayo Clinic Proceedings·David S KnopmanRonald C Petersen
Nov 13, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Judith Neugroschl, Kenneth L Davis
Oct 19, 2007·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Julie S SnowdenDavid Mann
Apr 5, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Cheryl L StopfordDavid Neary
Jan 5, 2002·Acta Clinica Belgica·P Cras
Oct 15, 2013·International Journal of Geriatric Psychiatry·Christopher M Davison, John T O'Brien
Oct 22, 2005·Lancet Neurology·David NearyDavid Mann
Oct 6, 2001·Radiologic Clinics of North America·R L Van HeertumR A Fawwaz
Apr 27, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Victor L VillemagneC L Masters
Apr 3, 2010·Neurobiology of Aging·Neelesh K NadkarniSandra E Black
Oct 5, 2010·Neuropsychologia·Marc RousseauxMarie Anne Mackowiak-Cordoliani
Jul 18, 2008·Handbook of Clinical Neurology·Gil D RabinoviciBruce L Miller
Mar 18, 2008·Revue neurologique·S AuriacombeUNKNOWN Groupe de consensus Théma
Oct 6, 2001·Arquivos de neuro-psiquiatria·M RadanovicP Caramelli
Jun 2, 2017·AJR. American Journal of Roentgenology·Mona ElSheikhJohn Huston
Dec 20, 2002·Journal of Geriatric Psychiatry and Neurology·Satoshi MinoshimaDavid E Kuhl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.