Abstract
Malignant lymphoma involving the salivary glands is a rare entity that accounts for only 1 to 4% of all salivary gland tumors. We have analyzed the clinical features of MALT lymphoma of the salivary glands in 7 patients whom we have treated in the past 10 years, including data from 43 patients in the literature. The most common symptom was persistent or progressive swelling of the salivary glands without pain or facial palsy. The affected glands were the unilateral parotid in 62%, the unilateral submandibular gland in 6.8%, and the bilateral parotid or submandibular gland in 6.8%. The salivary gland swelling as evaluated by MRI or ultrasonography consisted of a localized solitary tumor in 68.9%, multiple tumors in 10.3%, and diffuse swelling of the gland in 26.1%. In 24 out of 50 patients, MALT lymphoma developed on the basis of Sjögren's syndrome. As for diagnosis, malignant lymphoma was suspected only in 4 cases out of 11 (36.7%) based on the fine needle aspiration cytology. In all patients, a definitive diagnosis was obtained based on histopathological study of the localized tumor or the biopsy specimens. When patients with Sjögren's syndrome have developed persistent swelling of the salivary glands, it is necessary to rule ...Continue Reading
References
Oct 15, 1983·Cancer·P Isaacson, D H Wright
Sep 6, 2007·Leukemia & Lymphoma·Masaru KojimaNobuhide Masawa
Feb 12, 2008·Blood·Karin Ekström SmedbyWendy Cozen
Jun 9, 2009·The Laryngoscope·Hiroshi IwaiRyuichi Amakawa
Nov 13, 2009·Journal of Clinical and Experimental Hematopathology : JCEH·Masaru KojimaHiroshi Inagaki
Aug 26, 2010·Head & Neck·Marlene TrochMarkus Raderer
Nov 16, 2010·International Journal of Radiation Oncology, Biology, Physics·Yavuz AnacakMahmut Ozsahin
Aug 17, 2011·The Journal of Rheumatology·Rodney P E PollardGustaaf W van Imhoff
Dec 20, 2011·Acta Haematologica·Sung Yong OhCheolwon Suh
Feb 3, 2012·European Journal of Radiology·Hiroki KatoYoshinobu Hirose
Feb 22, 2012·Japanese Journal of Clinical Oncology·Yorihisa OritaTadashi Yoshino
Dec 4, 2012·The Laryngoscope·Etienne WyssAndreas Arnold
Apr 12, 2013·The Laryngoscope·Aaron J FeinsteinBenjamin L Judson
May 15, 2013·Seminars in Arthritis and Rheumatism·Anna P RisseladaJohannes W J Bijlsma
Nov 16, 2013·Journal of Autoimmunity·Luca QuartuccioSalvatore De Vita