A clinical study of autologous bone marrow mononuclear cells for cerebral palsy patients: a new frontier

Stem Cells International
Alok SharmaPrerna Badhe

Abstract

Cerebral palsy is a nonprogressive heterogeneous group of neurological disorders with a growing rate of prevalence. Recently, cellular therapy is emerging as a potential novel treatment strategy for cerebral palsy. The various mechanisms by which cellular therapy works include neuroprotection, immunomodulation, neurorestoration, and neurogenesis. We conducted an open label, nonrandomized study on 40 cases of cerebral palsy with an aim of evaluating the benefit of cellular therapy in combination with rehabilitation. These cases were administered autologous bone marrow mononuclear cells intrathecally. The follow-up was carried out at 1 week, 3 months, and 6 months after the intervention. Adverse events of the treatment were also monitored in this duration. Overall, at six months, 95% of patients showed improvements. The study population was further divided into diplegic, quadriplegic, and miscellaneous group of cerebral palsy. On statistical analysis, a significant association was established between the symptomatic improvements and cell therapy in diplegic and quadriplegic cerebral palsy. PET-CT scan done in 6 patients showed metabolic improvements in areas of the brain correlating to clinical improvements. The results of this s...Continue Reading

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Citations

Mar 30, 2017·HNO·A RoemerA Warnecke
Oct 11, 2017·Pediatric Research·Makoto NabetaniTakashi Hamazaki
Jun 22, 2018·Nature Reviews. Neurology·Xiaoming HuJun Chen
Aug 11, 2019·Molecular Neurobiology·María F Zappa VillarPaula C Reggiani
Feb 17, 2017·HNO·A RoemerA Warnecke
Apr 2, 2019·BioMed Research International·Anna M Kamelska-SadowskaIreneusz M Kowalski
Oct 9, 2016·Stem Cell Research & Therapy·Ariane RoemerAthanasia Warnecke
Dec 16, 2020·Neural Regeneration Research·Zhong-Yue LvJing Liu
May 20, 2021·Stem Cells Translational Medicine·Liem Nguyen ThanhMichael Heke
Aug 13, 2021·Stem Cell Reviews and Reports·Catherine BrégèreRaphael Guzman

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Methods Mentioned

BETA
bone marrow aspiration
fluorescence activated cell sorting

Clinical Trials Mentioned

NCT01978821

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