PMID: 7544756Sep 1, 1995Paper

A clinical study of lectin-reactive alpha-fetoprotein as an early indicator of hepatocellular carcinoma in the follow-up of cirrhotic patients

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
K ShirakiT Nakano

Abstract

Levels of two types of lectin-reactive alpha-fetoprotein (AFP), designated AFP-L3 and AFP-P4+P5, were analyzed with Lens culinaris agglutinin A and AFP-P4+P5 with erythroagglutinating phytohemagglutinin, respectively, in an attempt to determine the utility and significance of these macromolecules as early indicators of hepatocellular carcinoma during the periodic follow-up of cirrhotic patients. The subjects were 51 of 190 consecutive cirrhotic patients in whom hepatocellular carcinoma developed during a 6-year follow-up period and 21 cirrhotic patients without hepatocellular carcinoma. Serum AFP levels were of limited value to diagnose and predict hepatocellular carcinoma. The relative levels of AFP-L3 and AFP-P4+P5 in patients with hepatocellular carcinoma at the time of tumor detection were significantly higher than those in patients with cirrhosis. The sensitivity was 61%, and the specificity was 90%. Fourteen patients (48%) of 29 patients with small hepatocellular carcinomas less than 2 cm in diameter showed elevated percentage of lectin-reactive AFP. Retrospective examination of 21 patients who were positive for lectin-reactive AFP at diagnosis of hepatocellular carcinoma showed that 41% of them had already expressed lect...Continue Reading

References

Sep 5, 1991·The New England Journal of Medicine·M ColomboN Dioguardi
Jul 1, 1990·AJR. American Journal of Roentgenology·K TakayasuS Hirohashi
Oct 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H OkaK Kobayashi
Jan 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S Lok, C L Lai
Jan 1, 1988·Gastrointestinal Radiology·W L CuratiR E Steiner
Jan 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H OkaS Yamamoto
Jan 31, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·K ShimizuK Taketa
Jun 24, 1993·The New England Journal of Medicine·H TsukumaH Yamazaki
Jun 24, 1993·The New England Journal of Medicine·Y SatoS Nagataki

❮ Previous
Next ❯

Citations

Dec 22, 2005·International Journal of Clinical Oncology·Hideo YoshidaMasao Omata
Feb 11, 2005·Current Gastroenterology Reports·Morris Sherman
Mar 1, 2008·Hepatology International·Ryosuke TateishiMasao Omata
Oct 15, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·K ShimizuS Matsuura
Mar 11, 2005·Best Practice & Research. Clinical Gastroenterology·Morris Sherman
Nov 6, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·D LiS Satomura
Mar 25, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·M MiédougéG Serre
Feb 1, 1997·Journal of Hepatology·N SetaG Durand
Dec 2, 1999·Biochimica Et Biophysica Acta·E MiyoshiN Taniguchi
Oct 31, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·K Okuda
May 18, 2007·Journal of the American Chemical Society·Sarah R HansonChi-Huey Wong
Jun 26, 1999·Journal of Gastroenterology and Hepatology·P J Johnson
Feb 20, 2002·Journal of Gastroenterology and Hepatology·H OkaUNKNOWN Collaborative Hepato-Oncology Study Group of Japan
Jan 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Timothy M BlockAnand S Mehta
Mar 23, 2011·Journal of Gastroenterology and Hepatology·Kevin Z QuMaher Albitar
Mar 18, 2011·Journal of Gastroenterology and Hepatology·Kazuhiro NousoKazuhide Yamamoto
Feb 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Radoslav GoldmanMilos V Novotny
Feb 8, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Isao YamaguchiShinji Satomura
Feb 2, 2013·World Journal of Gastroenterology : WJG·Jong Young ChoiEun-Jee Oh
Oct 27, 2011·International Journal of Hepatology·Hock-Foong Lui
Nov 19, 2013·Journal of Cancer Research and Clinical Oncology·Sen YangWei-Ping Zhou
Sep 28, 2014·Best Practice & Research. Clinical Gastroenterology·Nicole Rich, Amit G Singal
Aug 19, 2007·Journal of the Chinese Medical Association : JCMA·Hau-Tsai ChengDeng-Yn Lin
Dec 13, 2012·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Xiao-Feng ZhangLe-Hua Shi
Aug 1, 2012·Seminars in Oncology·Cristina Della Corte, Massimo Colombo
Jun 22, 2011·Clinics in Liver Disease·Stevan A Gonzalez, Emmet B Keeffe
Mar 3, 2009·Medicina clínica·Alejandro FornerJordi Bruix
Oct 14, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Richard K SterlingMorris Sherman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.