A clinical study on glucosamine sulfate versus combination of glucosamine sulfate and NSAIDs in mild to moderate knee osteoarthritis.

TheScientificWorldJournal
Tamil SelvanElizabeth M Mathew

Abstract

Glucosamine may be effective in treating and possibly slowing the progression of Osteoarthritis (OA). It is believed Glucosamine supplements may help to stop cartilage breakdown, build cartilage and decrease swelling. The objective of this study was glucosamine sulfate versus combination of glucosamine sulfate and Non-Steroidal anti-inflammatory drugs (NSAID) in mild to moderate knee osteoarthritis. Subjects were randomly recruited from Rheumatology outpatient department after a diagnosis of mild or moderate Osteoarthritis. Study tools like patient data collection form, Western Ontario McMaster Universities Arthritis index (WOMAC) of Osteoarthritis questionnaires and Visual Analog Scale (VAS) were used. After 12 weeks, WOMAC total score the result showed that the significant mean difference between the group A and Group B treatment (P < 0.01), with a combination of GS and NSAIDs reducing VAS pain scores. Thus, it is found that Group B treatments over 4 and 12 weeks produced improved WOMAC and VAS grades. Study results may suggest that the Glucosamine Sulfate has a carryover effect like Disease modifying agents. Long-term treatment of Glucosamine Sulfate may reduce the dependence of NSAIDs usage and delay the disease progression...Continue Reading

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Citations

Jun 25, 2014·Environmental Toxicology and Pharmacology·Khadijeh JamialahmadiGholamreza Karimi
Jul 24, 2014·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Eduardo AnituaGorka Orive
Sep 15, 2012·Journal of Geriatric Physical Therapy·Robert ToppDavid Pieschel
Mar 22, 2014·The Korean Journal of Internal Medicine·Roberto PuentePablo Reyes
Dec 22, 2020·Therapeutic Advances in Musculoskeletal Disease·Kristin E YuFrancis Y Lee
Apr 3, 2021·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Christopher VannabouathongMohit Bhandari

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