A clinical trial of autologous adipose-derived regenerative cell transplantation for a postoperative enterocutaneous fistula

Surgery Today
Tsunekazu MizushimaMasaki Mori

Abstract

Adipose-derived stem cell (ADSC) transplantation is expected to be a minimally invasive, but effective, treatment for postoperative enterocutaneous fistulas associated with poor blood flow and chronic inflammation. The aim of this study was to assess the safety and efficacy of a novel ADSC therapy for this condition. We conducted an open-label, single-arm exploratory phase I study to assess the safety and efficacy of a novel ADSC therapy. Using the Celution system, we isolated adipose-derived regenerative cells (ADRCs) containing abundant ADSCs from liposuction-obtained gluteal adipose tissue. A mixture of ADRCs and fibrin glue was subsequently transplanted into the fistula, and ADRCs were percutaneously and endoscopically injected around the fistula. We evaluated the safety and feasibility of ADRC transplantation and fistula closure in six patients (UMIN000007316). ADRC transplantation was completed in all patients. The fistula closure rates were 83.3 % at 4 and 12 weeks and 100 % at 24 weeks. All patients had grade 1 pain and subcutaneous hemorrhage at the liposuction sites, but no serious adverse events related to this procedure were observed. Transplantation of autologous ADRCs is safe, feasible and advantageous, as it can ...Continue Reading

References

Apr 8, 1998·The British Journal of Surgery·E RullierM Parneix
Nov 11, 1999·Journal of Biomedical Materials Research·H Ohgushi, A I Caplan
Mar 23, 2002·Gastroenterology·David A SchwartzWilliam J Sandborn
Jun 8, 2002·Biochemical and Biophysical Research Communications·Kristine M SaffordHenry E Rice
Jan 10, 2003·The British Journal of Surgery·C EltonC R G Cohen
Mar 21, 2003·The Annals of Thoracic Surgery·Sunil RangappaEugene Kwang Sim Wei
Oct 8, 2003·Annals of Surgery·Victor W FazioConor P Delaney
Jan 8, 2004·JAMA : the Journal of the American Medical Association·Kane O PryorPeter A Goldstein
Oct 21, 2004·Best Practice & Research. Clinical Gastroenterology·W M Chambers, N J McC Mortensen
Oct 18, 2005·Journal of Cellular Biochemistry·Katia MareschiFranca Fagioli
Feb 21, 2006·Trends in Biotechnology·John K FraserMarc H Hedrick
Mar 23, 2006·International Journal of Colorectal Disease·J W P M OomenH van Goor
Dec 22, 2006·The New England Journal of Medicine·Kamal M F ItaniMurray A Abramson
Mar 11, 2009·Diseases of the Colon and Rectum·Damian Garcia-OlmoMaria Pascual
Jan 30, 2010·Surgical Endoscopy·Galal El-GazzazTracy Hull
Feb 7, 2012·The British Journal of Surgery·P M Sagar, J H Pemberton
Dec 1, 2012·Stem Cells Translational Medicine·Hidekazu TakahashiMasaki Mori
Sep 17, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Momokazu GotohYasuhito Funahashi
Mar 7, 2014·World Journal of Gastrointestinal Surgery·Freek DaamsJohan Frederik Lange

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Citations

Sep 9, 2016·Cell and Tissue Banking·Martin BoháčJán Koller
Feb 9, 2017·Obstetrics and Gynecology·Katarina Andjelkov, Zoran Maricic
Jul 20, 2017·Stem Cells Translational Medicine·Navid Mohamadpour ToyserkaniJens Ahm Sørensen
Sep 24, 2019·Expert Opinion on Biological Therapy·Isabel AndiaNatalia Burgos-Alonso
Jul 24, 2020·Regenerative Medicine·Fusanori YotsumotoShingo Miyamoto
Oct 14, 2017·Surgery Today·Tsunekazu MizushimaMasaki Mori
Nov 1, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yuichi KurodaRyosuke Kuroda
Sep 12, 2017·European Journal of Immunology·Alessandro NastiShuichi Kaneko
Nov 16, 2017·Stem Cells International·Lauren H MangumRobert J Christy
Aug 8, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Joshua Richard BurkeDavid Jayne

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