A clinical trial on the consistency of bilateral testicular tissue histopathology and Johnsen score: single side or bilateral side biopsy?

Oncotarget
Wen-Hao TangHui Jiang

Abstract

To evaluate and compare left and right testicular tissue histopathology and Johnsen score, and to investigate the necessity for bilateral testicular biopsy. We recruited180 patients with non-obstructiveazoospermia (NOA) on testicular biopsy who had undergonetesticular sperm aspiration (TESA). Pathological sections of testicular tissue were diagnosed by specially-assigned doctors, who evaluated pathological findings, determined the Johnsen score and confirmed for the presence or absence of sperm. Sperm positive rates for left and right testicular histopathology were 55.0% and 51.7% respectively, and the proportion of Johnsen scores≥8 for left and right testes were 53.3% and 50.0%, respectively. Cohen kappa values revealed that the identification of sperm in bilateral testicular samples was not consistent and was related to random effects; Optimized cut-off value for bilateral testicular volume was 11ml (Johnsen score ≥8), and optimized cut-off values of E2 on left and right testes were 144.5pmol/L and 133.5 pmol/L (Johnsen score≤7). However, age, serum prolactin (PRL), follicle stimulating hormone (FSH), luteinizing hormone (LH) and total testosterone (TT) levels were not accurate predictors for the existence of testicular sperm...Continue Reading

References

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May 10, 2011·Systems Biology in Reproductive Medicine·Ferial AslaniMohammad Reza Sadeghi
May 18, 2012·European Urology·Andreas JungwirthUNKNOWN European Association of Urology Working Group on Male Infertility
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Jun 18, 2015·Human Reproduction·V VloeberghsH Tournaye
May 14, 2016·BMC Urology·Giorgio FrancoErmanno Greco

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Citations

Sep 24, 2020·Reproduction in Domestic Animals = Zuchthygiene·Gustavo PaixãoRita Payan-Carreira
Apr 3, 2021·The Journal of International Medical Research·Lin QiYing C Su

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

SPSS21
cTESE
Excel
TESA

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