A Clinical Trial with Combined Transcranial Direct Current Stimulation and Attentional Bias Modification in Alcohol-Dependent Patients

Alcoholism, Clinical and Experimental Research
Tess E den UylReinout W Wiers

Abstract

Modifying attentional processes with attentional bias modification (ABM) might be a relevant add-on to treatment in addiction. This study investigated whether influencing cortical plasticity with transcranial direct current stimulation (tDCS) could increase training effects. tDCS could also help alcohol-dependent patients to overcome craving and reduce relapse, independent of training. These approaches were combined to investigate effects in the treatment of alcoholism. Ninety-eight patients (analytical sample = 83) were randomly assigned to 4 groups in a 2-by-2 factorial design. Patients received 4 sessions of ABM (control or real training) combined with 2 mA tDCS (active: 20 minutes or sham: 30 seconds) over the left dorsolateral prefrontal cortex. Alcohol bias and craving were assessed, and treatment outcome was measured as relapse after 1 year. Attentional bias scores indicated that during the training only the group with active tDCS and real ABM displayed an overall avoidance bias (p < 0.05). From pre- to postassessment, there were no main or interaction effects of tDCS and ABM on the bias scores, craving, or relapse (p > 0.2). However, effects on relapse after active tDCS were in the expected direction. There was no evide...Continue Reading

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Citations

Aug 28, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Noah S PhilipColleen A Hanlon
Nov 2, 2019·Neuroscience and Biobehavioral Reviews·Roberto U CofresíThomas M Piasecki
Nov 5, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hyun Joon Kim, Nyeonju Kang
Jul 28, 2020·The International Journal of Neuropsychopharmacology·Felipe FregniUNKNOWN Neuromodulation Center Working Group
Nov 13, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Juliana Teti MayerDjamila Bennabi

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