A clinically significant erythrocyte antibody detectable only by 51Cr survival studies

Transfusion
M L BaldwinG Garratty

Abstract

Hemolytic transfusion reactions typically are explained by red cell serologic incompatibilities. We describe a patient in whom a clinically significant red cell alloantibody could not be demonstrated, despite the occurrence of several clinically severe hemolytic reactions. Serologic studies using multiple techniques demonstrated only an anti-Bga; these studies included standard procedures as well as more sensitive experimental techniques. A 51Cr survival study using red cells from a random unit, compatible in vitro with conventional techniques, showed 72 percent survival at 1 hour and 7 percent survival at 24 hours. R2R2 (hr" (e) negative) red cells in a second 51Cr survival study showed 90 percent survival at 1 hour and 92 percent survival at 6 hours. The patient was transfused with R2R2 units which were tolerated well and survived normally. Extensive serologic testing still demonstrated only an anti-Bga. A third 51Cr survival study, 10 months after the first study, with an R1R1 (hr" (e) positive) sample showed 90 percent survival at 1 hour and 42 percent survival at 6 hours. A fourth study using a larger aliquot of R2R2 (hr"(e)negative) 51Cr-labeled red cells, examined over 2 weeks showed a near normal 21-day survival of 50 p...Continue Reading

Citations

Feb 1, 1987·World Journal of Surgery·H Seyfried, I Walewska
Jan 19, 2012·Veterinary Clinical Pathology·Margaret C MudgeSean D Owens
Oct 1, 1993·Nuclear Medicine and Biology·R A de VriesA Van de Wiel
Jul 26, 2005·Seminars in Hematology·George Garratty
Nov 5, 2019·Transfusion Medicine Reviews·Connie M ArthurSean R Stowell

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