A clinicopathologic and molecular study of follicular lymphoma in Taiwan

Clinical Lymphoma & Myeloma
Shih-Sung ChuangHui-Hwa Tseng

Abstract

The clinicopathologic and molecular features of follicular lymphoma (FL) in Taiwan have not been well defined. We conducted a retrospective study including history review, immunohistochemistry, and molecular study for the major breakpoint region (MBR) of t(14;18) and correlated these findings with survival. Sixty-five FLs were identified, with a male to female ratio of 1.9:1 and a median age of 63 years (mean, 60 years). Sixty cases (92%) were nodal, 4 (6%) were extranodal, and 1 (2%) was indeterminate. The median ages of the nodal and extranodal cases were 63 years and 44 years, respectively. Disease staging in 59 patients included 15 patients (25%) with stage I disease, 14 (24%) with stage II, 20 (34%) with stage III, and 10 (17%) with stage IV. Forty-four patients received chemotherapy, 2 patients received chemotherapy with palliative radiation therapy, and 13 patients received supportive treatment/observation. The 5-year survival rate was 52.6%. The cases were classified as grades 1 (n = 27; 42%), 2 (n = 22; 34%), 3A (n = 13; 20%), and 3B (n = 3; 5%). Twenty cases (31%) were positive for MBR, including 19 of 57 (33%) nodal cases and 1 of 4 (25%) primary extanodal FLs. Patients with low-stage disease (stages I/II) had a bett...Continue Reading

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Citations

Jul 24, 2007·Pathology, Research and Practice·Shih-Sung ChuangChao-Jung Tsao
May 24, 2008·International Journal of Laboratory Hematology·S I IsmailM S Tarawneh
Aug 31, 2011·Pediatric Hematology and Oncology·Sheau-Fang YangShih-Sung Chuang
Aug 23, 2008·Journal of Clinical Gastroenterology·Wan-Ting HuangShih-Sung Chuang

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