PMID: 2109298Feb 1, 1990Paper

A clinicopathologic study of three carcinoid tumors metastatic to the orbit. Immunohistochemical, ultrastructural, and DNA flow cytometric studies

Ophthalmology
D J ShetlarM Boniuk

Abstract

Three patients with histopathologically proven orbital metastatic lesions from a carcinoid tumor are reported. Computed tomography (CT) disclosed a well-circumscribed orbital mass in two of three cases. Each tumor was studied by both light and electron microscopy as well as immunohistochemistry and DNA flow cytometry. A review of the literature discloses the relatively rare occurrence of carcinoid tumors metastasizing to the eye and orbit. With the exception of one case, the reported metastatic carcinoid tumors to the uvea all developed from primary bronchial carcinoids. In contrast, the vast majority of the reported orbital metastases arose from ileal carcinoids. Immunohistochemical markers such as chromogranin A, synaptophysin, and serotonin have proven to be useful diagnostic tools in evaluating carcinoid tumors. Furthermore, DNA flow cytometry may be of prognostic value in patients with metastatic carcinoid tumor.

Citations

Oct 9, 2015·Clinical Nuclear Medicine·William MakisAlexander J B McEwan
Sep 7, 2004·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Vasuki SivagnanavelMuriel Buxton-Thomas
May 18, 2013·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Kian EftekhariMadhura A Tamhankar
Jun 11, 2011·AJNR. American Journal of Neuroradiology·A GuptaC D Phillips
Jun 1, 1992·Endocrine Pathology·Ingrid Zbieranowski, David Murray
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Feb 23, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Olivera Casar BorotaSigurd Lindal
Jun 5, 2020·Ophthalmic Plastic and Reconstructive Surgery·Hamzah MustakDaniel Rootman
Nov 18, 2021·European Journal of Ophthalmology·Giorgio AlbaneseRaghavan Sampath

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