Abstract
To investigate the relationship between adenoid basal carcinoma (ABC), adenoid cystic carcinoma (ACC) and squamous cell carcinoma (SCC) in the uterine cervix. We analysed the clinicopathological and molecular features in two pure ABCs, 15 SCCs with ABC-/ACC-like features and seven basaloid SCCs (BSCCs) by chart review, immunohistochemistry, human papillomavirus (HPV) RNA in-situ hybridisation and fluorescence in-situ hybridisation. All patients were alive with no evidence of disease, except for one patient with ACC-like features who died of disease at 18 months post diagnosis. The mixed carcinomas comprised variable SCCs and ABC-/ACC-like components displaying vague transitional zones. All components consistently showed diffuse p16, p63 and SOX2, variable cytokeratin (CK)7 and CK17 and rare Ber-EP4 and MYB expression; there was a substantially lower Ki67 index in pure ABCs and the ABC-like components. The ACC-like components showed no myoepithelial differentiation (SMA, calponin and S100) and MYB gene fusions. CK7, CK17 and Ber-EP4 were characteristically stronger in BSCCs than in the mixed carcinomas (P < 0.01). High-risk HPV (HR-HPV) E6/E7 mRNA was detected in 12 mixed carcinomas and seven BSCCs, but not in pure ABCs. The HR-...Continue Reading
References
Jan 8, 1998·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·M W JonesS D Finkelstein
Jan 8, 1998·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W GraysonK Cooper
Apr 13, 1999·The American Journal of Surgical Pathology·W GraysonK Cooper
Apr 11, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·S RiethdorfT W Park
Aug 27, 2002·Advances in Anatomic Pathology·Wayne Grayson, Kumarasen Cooper
Feb 16, 2005·Human Pathology·Anil V ParwaniBrigitte M Ronnett
Sep 6, 2005·Oral Oncology·Dimitrios AndreadisCalypso Barbatis
Feb 1, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A Neil Crowson
Sep 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jolise E MartensJan W Arends
Jan 15, 2008·Gynecologic Oncology·Katsuhide IkedaToshiyuki Mitsuya
Dec 1, 2008·Head and Neck Pathology·Ryan WintersAbdelmonem Elhosseiny
May 17, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Louis B BrillHenry F Frierson
Nov 30, 2011·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Tai-Di ChenLi-yu Lee
Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michael HerfsChristopher P Crum
Jul 20, 2012·Human Pathology·Olivier KerdraonAgnès Wacrenier
Sep 26, 2012·The Journal of Pathology·Michael HerfsChristopher P Crum
Oct 13, 2012·The American Journal of Surgical Pathology·Justin A BishopWilliam H Westra
Oct 1, 2013·The American Journal of Surgical Pathology·Michael HerfsChristopher P Crum
Oct 31, 2013·Archives of Pathology & Laboratory Medicine·Katy R LinskeyRosalynn M Nazarian
Jan 23, 2014·European Journal of Protistology·Tomoko Yuasa, Osamu Takahashi
Jul 16, 2014·World Journal of Gastrointestinal Oncology·Zeeshan RamzanSergio Huerta
Aug 20, 2015·Diagnostic Pathology·Xiaohua ShiZhiyong Liang
Sep 10, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Abha GoyalBin Yang
Dec 10, 2015·The American Journal of Surgical Pathology·Deyin XingBrigitte M Ronnett
Sep 7, 2017·The American Journal of Surgical Pathology·Justin A BishopWilliam H Westra
Mar 7, 2019·Archives of Pathology & Laboratory Medicine·Chia-Chi Chen, Sheau-Fang Yang