A clinicopathological study and prognostic factor analysis of 177 salivary duct carcinoma patients from The Netherlands

International Journal of Cancer. Journal International Du Cancer
Eline BoonCarla M L van Herpen

Abstract

Salivary duct carcinoma (SDC) is a subtype of salivary gland cancer with a dismal prognosis and a need for better prognostication and novel treatments. The aim of this national cohort study was to investigate clinical outcome, prognostic factors, androgen receptor (AR) and human epidermal growth factor receptor 2 (HER2) expression. SDC patients diagnosed between 1990 and 2014 were identified by the Nationwide Network and Registry of Histo- and Cytopathology in the Netherlands (PALGA). Subsequently, medical records were evaluated and pathological diagnoses reviewed. Data were analyzed for overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS) and prognostic factors. AR was evaluated by immunohistochemistry (IHC), HER2 by IHC and fluorescent in-situ hybridization. A total of 177 patients were included. The median age was 65 years, 75% were male. At diagnosis, 68% presented with lymph node metastases and 6% with distant metastases. Median OS, DFS and DMFS were 51, 23 and 26 months, respectively. In patients presenting without distant metastases, the absolute number of positive lymph nodes was associated with poor OS and DMFS in a multivariable analysis. AR and HER2 were positive in 161/168 (96%...Continue Reading

References

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Citations

Nov 20, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hideaki TakahashiToshitaka Nagao
Jun 25, 2019·Oncotarget·Wim van Boxtel, Carla van Herpen
Apr 21, 2020·The Oncologist·Glenn J HannaNicole G Chau
May 19, 2020·Cancer Cytopathology·Masato NakaguroToshitaka Nagao
May 28, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Simon A MuellerMark J Cowley
Nov 21, 2019·International Journal of Cancer. Journal International Du Cancer·Wim van BoxtelCarla M van Herpen
May 10, 2020·Virchows Archiv : an International Journal of Pathology·Min-Shu HsiehYing-Ju Kuo
Oct 24, 2019·Cancer Treatment Reviews·Gerben LasscheCarla M L van Herpen
Dec 24, 2019·International Journal of Oral and Maxillofacial Surgery·Y M ParkE C Choi
Feb 13, 2021·Head & Neck·Gustavo SchvartsmanRenata Ferrarotto
Nov 17, 2020·Frontiers in Oncology·Larissa Di VilleneuveGustavo Schvartsman
Mar 12, 2021·Frontiers in Oncology·Takayoshi SuzukiAkihiro Homma
Jul 13, 2021·Frontiers in Oncology·Kristian EgebjergMorten Mau-Sørensen
Oct 2, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alan L Ho
Mar 26, 2019·Acta Cytologica·Kimberly Point du Jour, Christopher C Griffith

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Methods Mentioned

BETA
dissection
dissections

Software Mentioned

PALGA

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