Abstract
Only a few cases of paraneoplastic neurologic syndrome with multiple cranial palsies have been reported. This is the case report of a patient with small-cell lung cancer and a high titer of anti-Hu antibodies who developed a tonic left pupil and multiple cranial nerve palsies, including palsies of the left fifth through tenth nerves and both twelfth nerves, as in Garcin syndrome showing at least more than seven ipsilateral cranial nerve palsies, in the course of paraneoplastic sensory neuronopathy (PSN). Pathologic examination revealed no metastasis or direct invasion of malignancy with gliosis and perivascular inflammation throughout the brainstem, indicating paraneoplastic encephalomyelitis (PEM). The numbers of EBM11+ cells (probably reactive microglia), CD8+ cells, and CD4+ cells increased. Intracellular adhesion molecule-1 and lymphocyte function associated molecule-1 were expressed intensely on the endothelia of microvessels and were found to have infiltrated mononuclear cells around microvessels in the brainstem. Multiple cranial nerve palsies and their effects including the tonic pupil are likely due to the paraneoplastic effect of the primary systemic malignancy.
References
Jul 1, 1977·Annals of Neurology·M S HorwichJ B Posner
Mar 1, 1992·Medicine·J DalmauJ B Posner
Nov 1, 1991·Neurology·J DalmauJ B Posner
Dec 15, 1990·International Journal of Cancer. Journal International Du Cancer·L GuariniP B Fisher
May 1, 1990·Annals of Neurology·J DalmauJ B Posner
Feb 1, 1990·Neurology·F GrausC Rozman
Oct 1, 1989·Current Opinion in Immunology·V C Schad, J L Greenstein
Sep 1, 1988·Neurology·N E AndersonJ B Posner
Apr 1, 1988·European Journal of Immunology·M W MakgobaS Shaw
Jun 1, 1988·The Journal of Experimental Medicine·C D GregoryA B Rickinson
Jan 1, 1988·European Journal of Immunology·G J DoughertyN Hogg
Jun 1, 1984·Neurology·N PillayJ D Brown
Apr 1, 1995·Annals of Neurology·B Cannella, C S Raine
Jan 1, 1994·Neurology·W C JeanJ B Posner
Jan 1, 1993·European Neurology·F Graus, R Reñé
May 1, 1996·Annals of Neurology·E J Dropcho
Mar 1, 1996·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·P B CrinoA C Rosenquist
Citations
Mar 19, 2008·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Melissa W KoSteven L Galetta
Dec 3, 2002·Journal of the American Veterinary Medical Association·Jennifer L DavisSamuel L Jones
Dec 3, 2014·Neurologic Clinics·Shin C BehElliot M Frohman
Apr 14, 2010·The Journal of Headache and Pain·Geneviève DemarquayJérome Honnorat
Sep 6, 2005·Clinical Neurology and Neurosurgery·Joseph V Campellone, Alexandre Hageboutros
Aug 9, 2016·Rinshō shinkeigaku = Clinical neurology·Misako KaidoKeiko Tanaka
Jan 9, 2008·Current Opinion in Neurology·Helmut Wilhelm
Dec 19, 2019·Frontiers in Neurology·Lei ZhangJiajun Chen