A clinicopathological study of atypical leiomyomas: Benign variant leiomyoma or smooth-muscle tumor of uncertain malignant potential

Oncology Letters
Ioannis KalogiannidisDavid Rousso

Abstract

Atypical leiomyomas are histopathologically recognized by moderate to severe pleomorphic atypical tumor cells showing low mitotic counts without coagulative tumor cell necrosis. The histopathological features and clinical behavior of these tumors are unclear. The surgical management of these lesions includes myomectomy and hysterectomy. The current study presents 5 cases of women with atypical leiomyomas that were managed surgically. The clinicopathological characteristics of the patients and recurrences were analyzed. The median age of the patients was 43 years old. While 3 out of 5 patients were treated by hysterectomy (with or without salpingo-oophorectomy), the remaining 2 patients were treated by myomectomy. The median mitotic index was 3 mitotic figures/10 high-power fields. The post-operative course of all patients was uneventful, and there was no evidence of local or distant recurrence in a median follow-up time of 72 months. The treatment of choice for atypical leiomyomas is hysterectomy. However, myomectomy may be an option for fertility sparing cases. A thorough consultation with regard to the uncertain behavior of such tumors and a rigorous follow-up must be offered in such patients.

References

Jul 1, 1990·Cancer·G EchtZ Petrovich
Oct 1, 1981·Fertility and Sterility·V C Buttram, R C Reiter
Aug 1, 1996·The Journal of the American Association of Gynecologic Laparoscopists·C BullettiC Flamigni
Nov 14, 1997·The American Journal of Surgical Pathology·K A Downes, W R Hart
Oct 2, 1998·Human Reproduction·J B DubuissonC Nörgaard
Feb 19, 1999·Baillière's Clinical Obstetrics and Gynaecology·M A Lumsden, E M Wallace
Apr 4, 2009·Gynecologic Oncology·Saketh R GuntupalliAnais Malpica
May 7, 2009·The American Journal of Surgical Pathology·Philip P C IpPhilip B Clement
Oct 24, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Chang Ohk SungDuk-Soo Bae
Oct 27, 2009·Gynecologic Oncology·Emanuela D'Angelo, Jaime Prat
Feb 8, 2014·JAMA : the Journal of the American Medical Association·Kimberly A Kho, Ceana H Nezhat

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