A clinicopathological study of venous loops and reduplications in diabetic retinopathy

Acta Ophthalmologica Scandinavica
Toke Bek

Abstract

To study possible causes of the gradual venous occlusion that precedes the formation of venous loops and reduplications in diabetic retinopathy using histopathological techniques. Casts of the retinal vascular system from six eyes of five diabetic patients were used to identify venous loops and reduplications. Subsequently the lesions were studied by immunohistochemistry using antibodies against cellular and non-cellular components previously shown to be disturbed in the diabetic retina. In all eyes the venous abnormalities identified on the casts were accompanied by abnormal wall partitions dividing the venous lumen. These partitions consisted of a double layer of flat cells displaying immunoreactivity to von Willebrand factor and actin (endothelial cells), but not to glial fibrillary acid protein or S-100 protein (glial cells), CD3, CD20, CD68, or neutrophil elastase (leucocytes). Neutrophile granulocytes adhering to the walls of larger retinal venules were unrelated to the venous partition and to capillary occlusion in the adjacent retinal areas. Venous loops and reduplications are associated with partitions of the larger retinal venules consisting of a double layer of endothelial cells anchored to a thin basement membrane. ...Continue Reading

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Citations

Sep 3, 2011·Clinical Ophthalmology·Darin A NelsonAmiram Grinvald
Aug 25, 2015·Progress in Retinal and Eye Research·Alan W StittNoemi Lois
Dec 4, 2003·Acta Ophthalmologica Scandinavica·Einar StefánssonAnders Heijl
Jul 31, 2013·Progress in Retinal and Eye Research·Toke Bek
Apr 28, 2020·Investigative Ophthalmology & Visual Science·Dong AnChandrakumar Balaratnasingam
Sep 10, 2019·Investigative Ophthalmology & Visual Science·Line Petersen, Toke Bek

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