A clonal complex 12 methicillin-resistant Staphylococcus aureus strain, West Australian MRSA-59, harbors a novel pseudo-SCCmec element

Antimicrobial Agents and Chemotherapy
Stefan MoneckeRalf Ehricht

Abstract

A West Australian methicillin-resistant Staphylococcus aureus strain (WA MRSA-59) was characterized by microarray and sequencing. Its pseudo-staphylococcal cassette chromosome mec (SCCmec) element comprised dcs, Q9XB68-dcs, mvaS-SCC, Q5HJW6, dru, ugpQ, ydeM, mecA-mecR-mecI, txbi mecI, tnp IS431, copA2-mco (copper resistance), ydhK, arsC-arsB-arsR (arsenic resistance), open reading frame PT43, and per-2. Recombinase genes, xylR (mecR2), and PSM-mec (phenol-soluble modulin) were absent. We suggest that mec complex A should be split into two subtypes. One harbors PSM-mec and xylR (mecR2). It is found in SCCmec types II, III, and VIII. The second subtype, described herein, is present in WA MRSA-59 and some coagulase-negative staphylococci.

References

Jun 15, 2007·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·G W CoombsK J Christiansen
Sep 2, 2009·Antimicrobial Agents and Chemotherapy·UNKNOWN International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements (IWG-SCC)
Aug 15, 2012·Antimicrobial Agents and Chemotherapy·Stefan MoneckeRalf Ehricht
Mar 19, 2013·International Journal of Medical Microbiology : IJMM·Anna C Shore, David C Coleman
Mar 15, 2015·International Journal of Antimicrobial Agents·Matthew J EllingtonSharon J Peacock

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