PMID: 9529862Apr 8, 1998Paper

A Clonorchis sinensis-specific antigen that detects active human clonorchiasis

The Korean Journal of Parasitology
S I Kim

Abstract

A Clonorchis sinensis-specific antigen in excretory-secretory product of C. sinensis (CsE) was assessed in human clonorchiasis by immunoblot. Thirty and 7 kDa antigens of CsE2, one of four different batches of CsEs reacted strongly with infection sera from clonorchiasis patients; however, the antigens reacted weakly with 6-month post-treatment sera from praziquantel-cured cases, but were still highly detected by the sera from praziquantel-failed patients, indicating that the 30 and 7 kDa antigens can detect antibodies during an active infection. The 30 kDa antigen showed some cross reactions with sera from patients with Paragonimus westermani and Metagonimus yokogawai, while the 7 kDa antigen did not, suggesting that the 7 kDa antigen has high specificity. The 30 kDa antigen reacted with some past clonorchiasis sera, whereas the 7 kDa antigen did not, supporting that antibodies to the 7 kDa antigen are not present in sera from past clonorchiasis patients. In an endemic area, 92% (23/25) of active clonorchiasis patients and 91% (10/11) of mixed infection patients with C. sinensis and M. yokogawai had IgG antibodies to the 7 kDa antigen, while 40% (6/15) of past clonorchiasis individuals and 43% (3/7) of metagonimiasis patients c...Continue Reading

References

Sep 1, 1991·Kisaengch'unghak chapchi. The Korean journal of parasitology·T S YongP R Chung
Mar 1, 1991·Kisaengch'unghak chapchi. The Korean journal of parasitology·J KimS H Lee
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Jun 1, 1983·Kisaengch'unghak chapchi. The Korean journal of parasitology·Duk Young Min, Chin Thack Soh

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Citations

Dec 31, 2008·World Journal of Gastroenterology : WJG·Ho Gak KimYong Bum Yoon
Oct 13, 2010·Infectious Disease Clinics of North America·Chiara Braconi, Tushar Patel
Dec 1, 2006·Advances in Parasitology·Rafael ToledoBernard Fried
Jul 9, 2002·The Journal of Parasitology·Hye-Jeong LeeHak R Kim
Nov 19, 2002·The Journal of Parasitology·Byoung-Kuk NaTong-Soo Kim
Jan 5, 2002·The Korean Journal of Parasitology·S J HongS Y Kang
Oct 2, 1998·The Korean Journal of Parasitology·T S YongS M Lee
Jun 28, 2001·The Journal of Parasitology·H El AlaouiC P Vivarès
Aug 7, 2009·Interdisciplinary Perspectives on Infectious Diseases·Kaya Ghosh, Louis M Weiss
Jun 12, 2009·The Journal of Nursing Research : JNR·Chao-An HungJui-Yuan Huang
Dec 14, 2004·The Korean Journal of Parasitology·Shunyu LiSung-Tae Hong
Jan 14, 2000·The Korean Journal of Parasitology·S T HongS H Lee
Jun 21, 2002·The Korean Journal of Parasitology·Young-Bae ChungSung-Tae Hong
Sep 16, 2003·The Korean Journal of Parasitology·Min-Ho ChoiSung-Tae Hong
Apr 2, 2003·The Korean Journal of Parasitology·Min-Ho ChoiSung-Tae Hong
Jul 10, 2004·Clinical and Diagnostic Laboratory Immunology·Qin-Ping ZhaoTong-Soo Kim

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