A close developmental relationship between the lymphoid and myeloid lineages

Trends in Immunology
Hiroshi Kawamoto

Abstract

The classic dichotomy model of hematopoiesis postulates that the first step of differentiation beyond the multipotent hematopoietic stem cell generates the common myelo-erythroid progenitors and common lymphoid progenitors (CLPs). Previous studies in fetal mice showed, however, that myeloid potential persists in the T- and B-cell branches even after these lineages have diverged, indicating that the simple dichotomy model is invalid, at least for fetal hematopoiesis. Nevertheless, CLPs have persisted in models of adult hematopoiesis; results from several groups support the presence of CLPs in bone marrow. Recent evidence challenges the dichotomy model in the adult, and it is proposed here that the alternative myeloid-based model is applicable to both fetal and adult hematopoiesis.

References

Dec 1, 1991·The Journal of Experimental Medicine·L WuK Shortman
Oct 1, 1993·The Journal of Experimental Medicine·Y MatsuzakiH Nakauchi
Oct 1, 1996·Immunology Today·M A Borrello, R P Phipps
Sep 5, 1998·Immunity·J R Carlyle, J C Zúñiga-Pflücker
Mar 26, 2002·Nature Reviews. Immunology·Yoshimoto Katsura
Oct 9, 2002·Immunological Reviews·Freddy RadtkeH Robson MacDonald
Oct 9, 2002·Immunological Reviews·Paul W KincadeMaria Isabel D Rossi
Jan 7, 2003·Nature Immunology·David AllmanAvinash Bhandoola
Feb 11, 2004·The Journal of Experimental Medicine·Lisa BorghesiRachel M Gerstein
May 28, 2004·Cell·Huafeng XieThomas Graf
Nov 9, 2004·Trends in Immunology·Yoshihiro BabaPaul W Kincade
Apr 19, 2005·Genes & Development·Tom N TaghonEllen V Rothenberg
Apr 23, 2005·Blood·Benjamin C HarmanGraham Anderson
Jun 14, 2005·Nature Immunology·Joanne B TanCynthia J Guidos
Jun 23, 2005·European Journal of Immunology·Gina BalciunaiteAntonius G Rolink
Jun 29, 2005·The Journal of Experimental Medicine·Claudia Benz, Conrad C Bleul
Jun 29, 2005·The Journal of Experimental Medicine·Howard T Petrie, Paul W Kincade
Sep 20, 2005·Immunity·Valerie P ZediakAvinash Bhandoola

❮ Previous
Next ❯

Citations

Dec 16, 2006·Nature Reviews. Immunology·Ken Shortman, Shalin H Naik
Dec 22, 2007·Nature Reviews. Immunology·Ellen V RothenbergMary A Yui
Jan 8, 2010·International Immunology·Hiroshi KawamotoYoshimoto Katsura
May 31, 2007·Current Opinion in Hematology·Ellen V Rothenberg
Nov 5, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sophia L YoheRobert W McKenna
Sep 19, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giacoma De TullioAttilio Guarini
Nov 18, 2015·Molecular Immunology·Lv-Yun ZhuJian-Zhong Shao
Sep 11, 2007·Trends in Immunology·Geoffrey BrownRod Ceredig
Jun 5, 2007·Biochimie·P Fitzgerald-Bocarsly, D Feng
Apr 8, 2009·European Journal of Immunology·Thomas Boehm
Nov 17, 2007·European Journal of Haematology·Maiko KatoYoshimoto Katsura
Jun 12, 2012·American Journal of Hematology·Jorge G RossiMaría S Felice
Apr 26, 2012·European Journal of Immunology·Jixin GaoYufeng Liu
Mar 12, 2013·Cytometry. Part B, Clinical Cytometry·Khaliqur RahmanAnurag Mehta
Oct 26, 2010·Immunological Reviews·Hiroshi KawamotoYoshimoto Katsura
Jul 14, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Rig VardhanJasjit Singh
Jan 1, 2013·Annual Review of Animal Biosciences·David ParraJ Oriol Sunyer
Jul 6, 2007·Leukemia·E G WeirM J Borowitz
Apr 11, 2008·Nature·Haruka WadaHiroshi Kawamoto
Mar 14, 2009·Nature Reviews. Immunology·Rhodri CeredigGeoffrey Brown
Feb 22, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cara L HaymakerHabib Zaghouani
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·S Scott PerryXiao-Hong Sun
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kyoko MasudaHiroshi Kawamoto
Jul 3, 2017·International Journal of Hematology·Suguru UemuraYoshiyuki Kosaka
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesca B AielloScott K Durum
Jun 17, 2019·Developmental and Comparative Immunology·Sunita PatelManish Kumar Tripathi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.