A closer look at the behaviour of milk lipids during digestion

Chemistry and Physics of Lipids
Andrew J ClulowBen J Boyd

Abstract

Milk has recently been reported to form complex self-assembled liquid crystalline structures during digestion by lipolytic enzymes. The formation of cubic phases at the endpoint of digestion was of particular interest as this requires a fine balance in self-assembly. This manuscript probes the robustness of the kinetic structural behaviour when milk is subjected to a range of processes that are encountered by milk and/or are relevant to the use of milk in pharmaceutical applications (homogenisation, lyophilisation, freeze-thawing and freeze-drying) using time-resolved small angle X-ray scattering (TR-SAXS). The nature of the persistent lamellar phase that occurs during digestion is elucidated using SAXS and X-ray photoelectron spectroscopy, and the interplay between the formation of structured mesophases and the evolution of particle size during digestion is determined using laser light scattering studies. This closer look at milk lipids during digestion establishes the dependence of the structural behaviour of milk on lipid composition and not processing, and clarifies the phase behaviour and kinetic effects on particle size distribution under lipolytic conditions.

Citations

Jun 22, 2019·Advanced Materials·Raffaele MezzengaLaurent Sagalowicz
Sep 17, 2020·Drug Delivery and Translational Research·Gisela RamirezBen J Boyd
Dec 28, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chelsea R ThornNicky Thomas
Apr 1, 2021·Journal of Agricultural and Food Chemistry·Hualu ZhouDavid Julian McClements
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Anna C PhamBen J Boyd
Aug 26, 2021·Biochemical Society Transactions·Ben J Boyd, Andrew J Clulow
Dec 17, 2021·Scientific Reports·Paulo A Da Costa FilhoEric Poitevin

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