A closer look at Warthin tumors and the t(11;19)

Cancer Genetics and Cytogenetics
André FehrJörn Bullerdiek

Abstract

The translocation t(11;19)(q21;p13) has been described in mucoepidermoid carcinoma (MEC) and rarely in Warthin tumors (WT), both tumors of the salivary gland. The translocation creates a fusion gene in which exon 1 of CRTC1 is linked to exons 2-5 of MAML2. To verify the translocation in WT, we performed nested reverse transcriptase-polymerase chain reaction using RNA from 48 WTs. This revealed the t(11;19)(q21;p13) translocation and expression of the chimeric gene in two metaplastic WT samples, but in none of the remaining ordinary 46 WTs. On review, the two positive cases were classified as tumors highly suspect for MEC. Indeed, our experience and published observations of the t(11;19)(q21;p13) translocation in WT reveal that only a small subset of WTs are positive, and that these tumors are often classified as infarcted or metaplastic WT, known to overlap considerably with MEC on purely morphological grounds. We therefore conclude that the presence of the t(11;19)(q21;p13) rearrangement favors a diagnosis of MEC.

References

Jan 1, 1991·Genes, Chromosomes & Cancer·B JohanssonF Mitelman
Jun 1, 1989·Clinical Otolaryngology and Allied Sciences·J W Eveson, R A Cawson
Jun 1, 1994·Cancer Genetics and Cytogenetics·A NordkvistG Stenman
Dec 31, 1998·Virchows Archiv : an International Journal of Pathology·G StenmanJ Mark
Sep 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Vadim IourgenkoMark A Labow
Feb 25, 2005·Genes, Chromosomes & Cancer·Afrouz BehboudiGöran Stenman
Mar 6, 2007·Genes, Chromosomes & Cancer·Marta WinnesGöran Stenman

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Citations

Jul 4, 2013·Head and Neck Pathology·Göran Stenman
Apr 1, 2010·Indian Journal of Surgical Oncology·Vincent L M Vander PoortenPaul M J Clement
Oct 27, 2012·Expert Review of Anticancer Therapy·Guy AndryJohannes A Langendijk
Dec 1, 2012·Surgical Pathology Clinics·Jennifer L Hunt
Dec 1, 2011·Surgical Pathology Clinics·Raja R Seethala, E Leon Barnes
Dec 16, 2010·Cancer Genetics and Cytogenetics·Avery A Sandberg, Aurelia M Meloni-Ehrig
Dec 1, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Lorena GallegoLucas Villalaín
Dec 20, 2015·Genome Medicine·Chandan Kumar-SinhaArul M Chinnaiyan
Jul 24, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Iain David O'Neill
May 16, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Matteo RotelliniAlessandro Franchi
Oct 15, 2009·Genes, Chromosomes & Cancer·Sarah L AnzickFrederic J Kaye
Apr 16, 2016·Journal of Cutaneous Pathology·Claire TingaudValérie Costes
Mar 19, 2015·International Journal of Surgical Pathology·Carlos N Prieto-GranadaJames Mueller
Jul 30, 2017·Diagnostic Cytopathology·Jen-Fan HangJustin A Bishop
Sep 15, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Takahisa NakayamaHiroshi Inagaki
Jul 1, 2010·The American Journal of Surgical Pathology·Raja R SeethalaMarina N Nikiforova
Oct 28, 2017·The American Journal of Surgical Pathology·Alena SkálováAlfio Ferlito
Aug 1, 2012·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Till Sebastian ClauditzWaldemar Wilczak
Oct 13, 2015·The American Journal of Surgical Pathology·Kenichiro IshibashiHiroshi Inagaki
Feb 25, 2017·Archives of Pathology & Laboratory Medicine·Christopher C GriffithKelly R Magliocca
Apr 16, 2017·Diagnostic Cytopathology·Christopher C GriffithAlessandra C Schmitt
Jun 23, 2019·Head and Neck Pathology·Daniel J Zaccarini, Kamal K Khurana
Mar 31, 2020·Virchows Archiv : an International Journal of Pathology·Michał BieńkowskiWojciech Biernat
Apr 8, 2020·Cytopathology : Official Journal of the British Society for Clinical Cytology·Mirna SučićFabijan Knežević
Jan 19, 2011·Virchows Archiv : an International Journal of Pathology·Jacinthe ChenevertSimion I Chiosea
Feb 20, 2014·Oncology Reports·Silke WemmertBernhard Schick
Jun 11, 2009·Molecular Cancer Therapeutics·Frederic J Kaye
Apr 30, 2011·Archives of Pathology & Laboratory Medicine·Jennifer L Hunt
Jul 8, 2021·Virchows Archiv : an International Journal of Pathology·André FehrThomas Löning
Mar 26, 2019·Acta Cytologica·Kimberly Point du Jour, Christopher C Griffith

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