A cluster of protein kinases and phosphatases modulated in fetal Down syndrome (trisomy 21) brain

Amino Acids
Rachel WeitzdoerferG Lubec

Abstract

Down syndrome (DS; trisomy 21) is the most frequent cause of mental retardation with major cognitive and behavioral deficits. Although a series of aberrant biochemical pathways has been reported, work on signaling proteins is limited. It was, therefore, the aim of the study to test a selection of protein kinases and phosphatases known to be essential for memory and learning mechanisms in fetal DS brain. 12 frontal cortices from DS brain were compared to 12 frontal cortices from controls obtained at legal abortions. Proteins were extracted from brains and western blotting with specific antibodies was carried out. Primary results were used for networking (IntAct Molecular Interaction Database) and individual predicted pathway components were subsequently quantified by western blotting. Levels of calcium-calmodulin kinase II alpha, transforming growth factor beta-activated kinase 1 as well as phosphatase and tensin homolog (PTEN) were reduced in cortex of DS subjects and network generation pointed to interaction between PTEN and the dendritic spine protein drebrin that was subsequently determined and reduced levels were observed. The findings of reduced levels of cognitive-function-related protein kinases and the phosphatase may b...Continue Reading

References

Nov 1, 1977·The Journal of Pediatrics·B LaVeck, G D LaVeck
Sep 20, 1996·Neuroscience Letters·G BernertG Lubec
Aug 31, 2001·Biochemical and Biophysical Research Communications·B LubecM Fountoulakis
Jan 5, 2002·Journal of Neural Transmission. Supplementum·R WeitzdoerferG Lubec
Jan 5, 2002·Journal of Neural Transmission. Supplementum·R WeitzdoerferG Lubec
Jun 11, 2002·Biochemical and Biophysical Research Communications·Rachel WeitzdoerferGert Lubec
Nov 6, 2002·Journal of Biochemistry·Naoaki Saito, Yasuhito Shirai
Feb 27, 2003·Journal of Neurochemistry·Ephrem Engidawork, Gert Lubec
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Heather L HindsVadim Y Bolshakov
Apr 8, 2004·Journal of Neural Transmission. Supplementum·U UnterbergerH Budka
May 4, 2007·Biochemical and Biophysical Research Communications·Zhenqi ZhuMarie C DeFrances
May 10, 2007·Nature Protocols·Sylva L SchwagerEdward D Sturrock
Sep 5, 2008·European Biophysics Journal : EBJ·Vladan LucićMary B Kennedy
Sep 27, 2008·Neuron·Gary A WaymanThomas R Soderling
Aug 18, 2009·Cellular and Molecular Life Sciences : CMLS·Joongkyu ParkKwang Chul Chung
Jun 18, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Isabelle BuardK Ulrich Bayer
Dec 29, 2010·Journal of Proteome Research·Charlotte Welinder, Lars Ekblad
Jun 2, 2011·Molecular and Cellular Neurosciences·Richard M GustinRoger J Colbran
Dec 20, 2011·Biochemical and Biophysical Research Communications·Robert Roskoski
Feb 16, 2012·Nature Reviews. Neuroscience·John LismanSridhar Raghavachari
Jan 1, 2006·CSH Protocols·Ed Harlow, David Lane
Jan 1, 2006·CSH Protocols·Ed Harlow, David Lane
Jun 22, 2012·Trends in Neurosciences·Steven J Coultrap, K Ulrich Bayer
Sep 25, 2012·Cellular Signalling·Tohru Ishitani, Shizuka Ishitani
Nov 14, 2012·Journal of Neuropathology and Experimental Neurology·Karol DowjatYu-Wen Hwang
Jan 4, 2013·Nature·Anna M LeeRobert O Messing
Feb 16, 2013·Molecular Brain·Magdalena Sanhueza, John Lisman
Sep 18, 2013·Learning & Memory·Karl Peter Giese, Keiko Mizuno
Oct 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anca B MihalasMollie K Meffert
Oct 25, 2013·CNS & Neurological Disorders Drug Targets·Walter BeckerFrancisco J Tejedor
Jan 24, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aurore ThomazeauOlivier J Manzoni
Jan 28, 2014·Experimental Neurobiology·Joongkyu Park, Kwang Chul Chung

❮ Previous
Next ❯

Citations

Jul 31, 2020·Acta Neuropathologica Communications·Sathish KumarJochen Walter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.