A cluster randomized trial of strategies to increase uptake amongst young women invited for their first cervical screen: The STRATEGIC trial

Journal of Medical Screening
Henry KitchenerC Roberts

Abstract

Objectives To measure the feasibility and effectiveness of interventions to increase cervical screening uptake amongst young women. Methods A two-phase cluster randomized trial conducted in general practices in the NHS Cervical Screening Programme. In Phase 1, women in practices randomized to intervention due for their first invitation to cervical screening received a pre-invitation leaflet and, separately, access to online booking. In Phase 2, non-attenders at six months were randomized to one of: vaginal self-sample kits sent unrequested or offered; timed appointments; nurse navigator; or the choice between nurse navigator or self-sample kits. Primary outcome was uplift in intervention vs. control practices, at 3 and 12 months post invitation. Results Phase 1 randomized 20,879 women. Neither pre-invitation leaflet nor online booking increased screening uptake by three months (18.8% pre-invitation leaflet vs. 19.2% control and 17.8% online booking vs. 17.2% control). Uptake was higher amongst human papillomavirus vaccinees at three months (OR 2.07, 95% CI 1.69-2.53, p < 0.001). Phase 2 randomized 10,126 non-attenders, with 32-34 clusters for each intervention and 100 clusters as controls. Sending self-sample kits increased upt...Continue Reading

References

Aug 5, 1997·American Journal of Health Promotion : AJHP·J O Prochaska, W F Velicer
Jun 11, 1999·Journal of the American Dietetic Association·G W GreeneJ O Prochaska
Feb 17, 2001·Statistics in Medicine·G M Raab, I Butcher
May 29, 2004·American Journal of Preventive Medicine·David GoldbergArthur Hoffman
Jul 14, 2007·Journal of Medical Screening·S R ColeG P Young
Jun 15, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·J WallerJ Wardle
Aug 29, 2014·The Medical Journal of Australia·Alison C BuddMarion Saville
Nov 8, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Paul G RitvoLinda Rabeneck
Aug 25, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F VerdoodtM Arbyn

❮ Previous
Next ❯

Citations

Dec 7, 2018·BMJ : British Medical Journal·Marc ArbynUNKNOWN Collaboration on Self-Sampling and HPV Testing
Oct 30, 2019·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Helen E CampbellOliver Rivero-Arias
Mar 26, 2019·The Journal of Nursing Research : JNR·Gonul Kurt, Aygul Akyuz
Jan 7, 2020·American Journal of Respiratory and Critical Care Medicine·Andrea N Burnett-Hartman, Renda Soylemez Wiener
Jul 29, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·J C Davies-OliveiraE J Crosbie
Oct 26, 2021·The Cochrane Database of Systematic Reviews·Helen StaleyKetankumar Gajjar
Jan 2, 2022·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Rebecca LandyAnita Ww Lim

❮ Previous
Next ❯

Methods Mentioned

BETA
lavage
Contraception

Clinical Trials Mentioned

ISRCTN52303479

Software Mentioned

Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.