A CMOS active pixel sensor system for laboratory- based x-ray diffraction studies of biological tissue

Physics in Medicine and Biology
Sarah E BohndiekRobert D Speller

Abstract

X-ray diffraction studies give material-specific information about biological tissue. Ideally, a large area, low noise, wide dynamic range digital x-ray detector is required for laboratory-based x-ray diffraction studies. The goal of this work is to introduce a novel imaging technology, the CMOS active pixel sensor (APS) that has the potential to fulfil all these requirements, and demonstrate its feasibility for coherent scatter imaging. A prototype CMOS APS has been included in an x-ray diffraction demonstration system. An industrial x-ray source with appropriate beam filtration is used to perform angle dispersive x-ray diffraction (ADXRD). Optimization of the experimental set-up is detailed including collimator options and detector operating parameters. Scatter signatures are measured for 11 different materials, covering three medical applications: breast cancer diagnosis, kidney stone identification and bone mineral density calculations. Scatter signatures are also recorded for three mixed samples of known composition. Results are verified using two independent models for predicting the APS scatter signature: (1) a linear systems model of the APS and (2) a linear superposition integral combining known monochromatic scatter s...Continue Reading

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Citations

Apr 5, 2011·The Review of Scientific Instruments·J A GriffithsG J Royle
Apr 23, 2009·Molecular Oncology·Leonard Fass
May 23, 2008·Physics in Medicine and Biology·J P F OsmondP M Evans
Nov 6, 2009·Nature Reviews. Urology·Ricardo A Natalin, Jaime Landman
Jul 6, 2010·Physics in Medicine and Biology·Peter R T MunroAlessandro Olivo
Feb 3, 2018·Physics in Medicine and Biology·Yi ZhengJennifer Griffiths
May 16, 2009·Physics in Medicine and Biology·Sarah E BohndiekRobert D Speller
May 30, 2009·Physics in Medicine and Biology·Wael M Elshemey, Wafaa B Elsharkawy
Mar 7, 2021·Materials·Dionysios LinardatosChristos Michail
May 26, 2010·Analytical Chemistry·Kouichi TsujiChul-Un Ro

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