PMID: 8962472Nov 29, 1996Paper

A codiffusing system as a novel model for capillary wall charge selectivity

Biophysical Chemistry
M F Smit, W D Comper

Abstract

The electrostatic interaction associated with polyion-polyion interaction has been thought to be the basis for the differential transport of charged transport probes across the capillary wall. The charge of the transport probe may interact with the negative charges of capillary wall cell surfaces and the intercellular glycocalyx or extracellular matrix. This study has set out to quantitate the exact nature of the polyion-polyion interaction through the theoretical and experimental study of the partition-diffusion of albumin in solutions of anionic polysaccharides (dextran sulfate or heparin) at concentrations up to 250 meq 1(-1) or at an average intercharge distance of 2.2 nm, as compared with solutions of uncharged dextran at the same volume concentration. The results demonstrate that the albumin partition-diffusion is exactly the same in dextran sulfate, heparin and uncharged dextran matrices of the same polymer volume fraction. These results confirm previous studies from this laboratory that the charge effect through polyion-polyion interaction under physiological conditions is negligible.

References

Jan 1, 1978·The Journal of Clinical Investigation·M P BohrerB M Brenner
Nov 1, 1978·The Biochemical Journal·W D Comper, T C Laurent
May 28, 1976·Biochimica Et Biophysica Acta·J M Snowden, A Maroudas
Feb 1, 1988·The American Journal of Physiology·J H DominguezJ B Puschett
Jan 1, 1985·Advances in Protein Chemistry·T Peters
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Jan 1, 1970·The Biochemical Journal·A G Ogston, P Silpananta
Oct 1, 1968·The Biochemical Journal·E Edmond, A G Ogston
May 1, 1995·Kidney International·W D Comper, E F Glasgow
Oct 1, 1994·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Y AdalW D Comper

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Citations

Jan 10, 2004·The Journal of Laboratory and Clinical Medicine·Steven P Clavant, Wayne D Comper
May 7, 1999·Kidney International·G A EppelW D Comper
Jun 29, 2001·Pathologie-biologie·L RobertG Renard
Nov 16, 2007·Journal of the American Society of Nephrology : JASN·Tessa J M WijnhovenToin H van Kuppevelt
Mar 5, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Emanuel SchneckMotomu Tanaka
Jun 27, 2008·American Journal of Physiology. Renal Physiology·Wayne D ComperLeileata M Russo
Jul 17, 1999·The American Journal of Physiology·T M OsickaW D Comper
May 12, 1998·The American Journal of Physiology·M J BurneW D Comper
Apr 15, 1997·Archives of Biochemistry and Biophysics·M J BurneW D Comper
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Leileata M RussoWayne D Comper
Jun 20, 1998·Seminars in Radiation Oncology·F Yuan
Feb 29, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G A EppelW D Comper

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