Abstract
Protein-energy wasting (PEW) is highly prevalent in haemodialysis (HD) patients and associated with increased mortality and cardiovascular disease (CVD). Insulin-like growth factor 1 (IGF-1) correlates to markers of PEW and CVD. Disturbances in the growth hormone axis in end-stage renal disease (ESRD) could have an impact on survival through increased PEW and CVD. A cohort of 265 incident HD patients (median age 68 years, 59% males) was followed for 3 years. Subjects were categorized according to IGF-1 levels at dialysis initiation. Outcome and comorbidity data were retrieved from national registers. The Kaplan-Meier diagram and Cox proportional hazards model were used for the analysis of survival. Patients with IGF-1 levels in the lowest tertile were characterized by female sex, low creatinine, hypoalbuminemia and high C-reactive protein (CRP) levels. IGF-1 levels within the lowest tertile were associated with increased mortality [hazard ratio (HR) 2.4, 95% confidence interval (CI) 1.7-3.4]. This association persisted when corrected for demographic factors (age, sex) and comorbidities (diabetes mellitus, CVD, heart failure) in multivariable analysis. Including high-sensitivity C-reactive protein (hs-CRP) and serum creatinine i...Continue Reading
References
Aug 1, 1995·Kidney International·G A KaysenT A Depner
Sep 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J HimmelfarbD Spratt
Oct 1, 1993·Journal of Endocrinological Investigation·A CaufriezG Copinschi
Feb 27, 1997·The New England Journal of Medicine·D Le Roith
Mar 21, 1998·Kidney International·A R QureshiJ Bergström
May 7, 1999·Kidney International·P StenvinkelT Jogestrand
Nov 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·O HeimbürgerP Stenvinkel
Mar 30, 2005·Nephron. Clinical Practice·Chung-Ying HungChwei-Shiun Yang
Jan 5, 2006·European Journal of Clinical Nutrition·J AxelssonP Stenvinkel
Sep 25, 2007·Acta Oncologica·Katsiaryna HollAnnekatrin Lukanova
Jan 6, 2009·Seminars in Nephrology·Bo Feldt-Rasmussen, Meguid El Nahas
Jun 23, 2010·Clinical and Experimental Nephrology·Srinivas TeppalaCharumathi Sabanayagam
Dec 28, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nazanin NooriKamyar Kalantar-Zadeh
Jun 11, 2011·BMC Public Health·Jonas F LudvigssonPetra Otterblad Olausson
Jul 29, 2011·The Journal of Clinical Endocrinology and Metabolism·Anne Marij G BurgersOlaf M Dekkers
Nov 30, 2011·Kidney & Blood Pressure Research·Marta KalousováTomáš Zima
Jun 23, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Thiane Gama-AxelssonAbdul Rashid Qureshi
Feb 23, 2013·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Juan Jesús CarreroHarold A Franch
Aug 21, 2013·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Ilia BeberashviliZhan Averbukh
Nov 2, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Ting JiaAbdul Rashid Qureshi
Citations
Jun 18, 2016·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Bojan KnapŽeljka Večerić-Haler
Dec 8, 2017·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Vladimir PrelevicNikolina Basic-Jukic
Aug 3, 2018·Artificial Organs·Tadashi SuzukiMasahiro Abo
Mar 29, 2019·European Journal of Clinical Investigation·Towe StrålbergErik Nilsson
Jun 15, 2019·International Urology and Nephrology·Elżbieta Cecerska-HeryćBarbara Dołęgowska
Aug 28, 2020·International Urology and Nephrology·Vladimir PrelevicNikolina Basic-Jukic
Mar 25, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Garland A CampbellWarren K Bolton
Feb 21, 2021·Environmental Health and Preventive Medicine·Maki YamamotoYoshihiro Fukumoto
Apr 10, 2021·Journal of Clinical Neurology·Jeeun LeeByung Chul Lee