A collaboration investigating endocannabinoid signalling in brain and bone

Journal of Basic and Clinical Physiology and Pharmacology
Andreas Zimmer

Abstract

Investigations into the cellular and molecular mechanisms underlying the psychoactive effects of cannabis preparations have led to the discovery of the endocannabinoid system. Interest in the central nervous system effects was initially the main focus of the research, but it soon became evident that the endocannabinoid system affects virtually every organ. The research field has therefore experienced a tremendous growth over the last decade and is now truly interdisciplinary. This short review provides a personal account of an interdisciplinary collaboration between Itai Bab from the Hebrew University of Jerusalem and the author. It describes the discovery of the endocannabinoid system in bone and the analysis of its functions. I am summarising the role of CB1 signalling as a modulator of sympathetic inhibition of bone formation. Thus, activation of CB1 receptors on sympathetic nerve terminals in bone, presumably from endocannabinoids released from apposing osteoblasts, reduces the inhibition of bone formation of sympathetic norepinephrine. CB2 receptors on osteoblasts and osteoclasts also modulate the proliferation and functions of these cells. Thus, activation of CB2 stimulates bone formation and represses bone resorption, wh...Continue Reading

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Citations

Apr 21, 2019·International Journal of Molecular Sciences·Francesca RossiSilverio Perrotta
Apr 27, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Esther Shohami, Michal Horowitz
Jun 1, 2018·Scientific Reports·Abdullah Y MandourahDong L Barraclough
Oct 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saja BaraghithyJoseph Tam
Aug 9, 2019·The Journal of Clinical Endocrinology and Metabolism·Joel Ehrenkranz, Michael A Levine
Aug 17, 2020·Journal of Pediatric Gastroenterology and Nutrition·Chiara TortoraFrancesca Rossi
Oct 24, 2020·Journal of Pediatric Gastroenterology and Nutrition·Chiara TortoraFrancesca Rossi

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Methods Mentioned

BETA
pharmacotherapy

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