A collaborative knowledge base for cognitive phenomics

Molecular Psychiatry
F W SabbRobert M Bilder

Abstract

The human genome project has stimulated development of impressive repositories of biological knowledge at the genomic level and new knowledge bases are rapidly being developed in a 'bottom-up' fashion. In contrast, higher-level phenomics knowledge bases are underdeveloped, particularly with respect to the complex neuropsychiatric syndrome, symptom, cognitive, and neural systems phenotypes widely acknowledged as critical to advance molecular psychiatry research. This gap limits informatics strategies that could improve both the mining and representation of relevant knowledge, and help prioritize phenotypes for new research. Most existing structured knowledge bases also engage a limited set of contributors, and thus fail to leverage recent developments in social collaborative knowledge-building. We developed a collaborative annotation database to enable representation and sharing of empirical information about phenotypes important to neuropsychiatric research (www.Phenowiki.org). As a proof of concept, we focused on findings relevant to 'cognitive control', a neurocognitive construct considered important to multiple neuropsychiatric syndromes. Currently this knowledge base tabulates empirical findings about heritabilities and mea...Continue Reading

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Citations

Aug 15, 2009·Neuropsychology Review·Robert M Bilder
Jun 25, 2013·Brain and Cognition·Melissa-Ann MackieJin Fan
Nov 26, 2010·Journal of the International Neuropsychological Society : JINS·Robert M Bilder
Oct 3, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Athina MarkouThomas Steckler
Jul 28, 2009·Cognitive Neuropsychiatry·Robert M BilderRussell A Poldrack
Aug 13, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Carrie E BeardenDavid C Glahn
Apr 25, 2009·PLoS Computational Biology·Curt ScharfeRonald W Davis
Aug 6, 2011·Trends in Cognitive Sciences·Robert M BilderD Stott Parker
Aug 6, 2008·Current Opinion in Neurobiology·Russell A Poldrack
Apr 1, 2011·Topics in Cognitive Science·Carrie Figdor
Oct 1, 2010·Topics in Cognitive Science·Agatha LenartowiczRussell A Poldrack
Apr 24, 2014·British Journal of Psychology·Katharine N ThakkarRobert M Bilder
Jul 15, 2015·Annual Review of Neuroscience·Beatriz LunaRajpreet Chahal
May 19, 2009·Neuroscience·D Dickinson, B Elvevåg
Apr 7, 2009·Neuroscience·R M BilderN B Freimer
Oct 10, 2014·Consciousness and Cognition·Jolien C Francken, Marc Slors
Nov 14, 2018·The Clinical Neuropsychologist·Robert M Bilder, Steven P Reise
Feb 15, 2019·The Clinical Neuropsychologist·Thomas D Parsons, Tyler Duffield
Aug 15, 2018·Brain and Behavior·Fred W SabbCarrie E Bearden
Feb 12, 2011·Expert Review of Gastroenterology & Hepatology·Daniel P HolschneiderEmeran A Mayer
Jul 19, 2020·NeuroImage·Yoed N KenettAdam E Green
Dec 17, 2020·Journal of Medical Internet Research·Thomas Parsons, Tyler Duffield
Jul 1, 2021·Neuropsychiatric Disease and Treatment·Joseph A WonderlichJoanna E Steinglass
Aug 24, 2021·Frontiers in Psychology·Yoed N KenettAnjan Chatterjee

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