A collagen coated fabric vascular prosthesis as a punctureable A-V shunt

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Y NoishikiA Matsumoto

Abstract

A fabric vascular prosthesis sealed with succinylated collagen (SC) was developed as an arteriovenous (A-V) shunt graft for hemodialysis. The SC graft was soft, pliable, flexible, and puncturable, with quick hemostasis. A needle puncture made a smaller hole in the SC graft wall than in a control expanded-polytetrafluoroethylene (e-PTFE) graft such as is usually used for an A-V shunt. The SC graft was extremely hydrous, because it is sealed with water, which is absorbed into the intermolecular spaces of negatively charged collagen. The SC suspension was injected with pressure into a knitted fabric vascular prosthesis wall (water permeability, 1,200 ml) so as to become entangled in the Dacron network. The graft then was lyophilized and thermally cross-linked. Water leakage from six holes created by an 18 G needle puncture in vitro under water pressure of 120 mmHg was 34.5 +/- 29.9 ml/min in the SC graft and 169.9 +/- 38.5 ml/min in the control e-PTFE graft. Hemostatic time at six 18G needle puncture sites on grafts implanted in the abdomen of 12 dogs was 4.5 +/- 2.5 mins in the SC graft and 34.2 +/- 11.5 mins in the control graft. After implantation, the luminal surface of the SC grafts had a thinner thrombus layer than did the c...Continue Reading

Citations

Jul 30, 2019·Frontiers in Bioengineering and Biotechnology·Francesco CopesDiego Mantovani

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