A collagen microchannel scaffold carrying paclitaxel-liposomes induces neuronal differentiation of neural stem cells through Wnt/β-catenin signaling for spinal cord injury repair

Biomaterials
Xiaoran LiJianwu Dai

Abstract

Neural stem cells (NSCs) show potential for spinal cord injury (SCI) repair. However, the current challenge is to direct their differentiation into neurons in the lesion site. It has been demonstrated that transplanted NSCs primarily differentiated into astrocytes rather than neurons due to the adverse microenvironment. It was reported that microtubule-stabilizing agent paclitaxel (PTX) was able to reduce scarring and enhance intrinsic axon regeneration after SCI. In this study, the effect of PTX on NSC differentiation was studied. It was demonstrated for the first time that PTX could rescue myelin-inhibited neuronal differentiation of NSCs, and induced a higher neuronal differentiation as compared with that in normal microenvironment. Enhanced neuronal differentiation in normal microenvironment further validated that PTX was capable of inducing intrinsic neuronal differentiation of NSCs. Furthermore, a functional collagen scaffold was developed by loading PTX-encapsulated liposomes into a collagen microchannel scaffold, leading to a prolonged sustained release of PTX. When NSC-laden functional collagen scaffold was implanted into T8 complete transection site of rat spinal cord, the scaffold provided an instructive microenviron...Continue Reading

Citations

Nov 7, 2019·Journal of Cellular Physiology·Guidong ShiShiqing Feng
May 5, 2020·Advanced Healthcare Materials·Liangliang YangPatrick van Rijn
Jun 12, 2019·Pharmaceutics·Raluca Ioana TeleanuDaniel Mihai Teleanu
Apr 9, 2020·Frontiers in Bioengineering and Biotechnology·Fengxuan HanBin Li
Sep 19, 2020·International Journal of Molecular Sciences·Sathish Sundar Dhilip Kumar, Heidi Abrahamse
Aug 28, 2020·Micromachines·Georgia KastaniaDmitry Volodkin
Nov 3, 2020·Tissue Engineering. Part B, Reviews·Rafaela ZimmermannPatricia Pranke
Feb 10, 2021·Cell Transplantation·Liyi HuangQuan Wei
Mar 5, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chen ZhaoHaifeng Liu
Jul 9, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mahmoud HashemzaeiRamin Rezaee
Apr 3, 2021·Biomaterials·Xiaoyun LiuZhijun Zhang
Apr 9, 2021·International Journal of Pharmaceutics·Amina T Mneimneh, Mohammed M Mehanna
May 12, 2021·Nature Communications·Yanjing ZhuRongrong Zhu
Jun 15, 2021·European Journal of Medicinal Chemistry·Tingshen LiXin Meng
Sep 18, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Lauren E Kass, Juliane Nguyen
Oct 6, 2021·Journal of Peptide Science : an Official Publication of the European Peptide Society·Chengxing ZhangZongwu Deng
Jan 13, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sonali JanaSamit Kumar Nandi

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