A combination of a particular HLA-DP beta allele and an HLA-DQ heterodimer confers susceptibility to coeliac disease

Nature
T L BugawanH A Erlich

Abstract

Coeliac disease is an autoimmune disease of the intestinal mucosa, elicited by ingestion of wheat gluten in genetically susceptible individuals. Susceptibility to coeliac disease has been associated with the serologically defined variants DR3 and DR7 of the class II antigens encoded by the HLA-D region. Three related class II antigens, each consisting of an alpha and a beta glycoprotein chain, have been identified and are designated HLA-DR, HLA-DQ, and HLA-DP. These highly polymorphic transmembrane proteins bind peptides derived from the processing of foreign antigens and present them to T lymphocytes; they also influence the specificity of the mature T-cell repertoire. The role of HLA-DP polymorphism in susceptibility has not been as fully explored as that of the other class II antigens because of the complexity of the primed lymphocyte typing (PLT) method for determining DPw specificities. Here we use a new DNA-based method of HLA-DP typing to analyse the distribution of DP beta alleles in a group of coeliac disease patients and healthy controls. Two specific DP beta alleles (DPB4.2 and DPB3) are increased in the patient population. Comparison of the DP beta sequences suggests that the polymorphic residues at position 69 and ...Continue Reading

References

Oct 1, 1979·Tissue Antigens·M DeMarchiB Santini
Feb 20, 1987·Science·J G GuilletM L Gefter
Mar 1, 1989·The Journal of Clinical Investigation·M J SheehyB S Nepom
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G T HornH A Erlich
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M D HowellM F Kagnoff
Jan 1, 1989·The Journal of Experimental Medicine·L M SollidE Thorsby
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T H Watts, H M McConnell
Jul 1, 1985·Immunological Reviews·J TrowsdaleJ Bodmer
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S J ScharfH A Erlich
Jan 1, 1987·Methods in Enzymology·K B Mullis, F A Faloona
Apr 24, 1987·Cell·J W KapplerP Marrack
Sep 1, 1983·Clinical Immunology and Immunopathology·R TosiS Auricchio

❮ Previous
Next ❯

Citations

Nov 1, 1989·Journal of Clinical Immunology·H A Erlich
Jan 1, 1990·Immunogenetics·J W Dekker, S Easteal
Jan 1, 1989·Immunogenetics·W M RosenbergJ I Bell
Jan 1, 1992·Molecular Aspects of Medicine·M Baines, A Ebringer
Jul 1, 1990·Human Immunology·J G BodmerT Sasazuki
Nov 1, 1990·Human Immunology·G Mueller-EckhardtC Mueller-Eckhardt
Oct 1, 1992·Human Immunology·A UrlacherM M Tongio
May 1, 1992·Human Immunology·D A SavageC F McCarthy
Nov 1, 1992·Human Immunology·R P DongT Sasazuki
Jul 1, 1995·Human Immunology·J ArroyoM Sánchez-Pérez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
M F KagnoffH A Erlich
Proceedings of the National Academy of Sciences of the United States of America
A B BegovichH A Erlich
Proceedings of the National Academy of Sciences of the United States of America
M D HowellM F Kagnoff
© 2022 Meta ULC. All rights reserved