A combination of a transforming growth factor-beta antagonist and an inhibitor of cyclooxygenase is an effective treatment for murine pulmonary tuberculosis.

Clinical and Experimental Immunology
Rogelio Hernandez-PandoFernando López-Casillas

Abstract

Transforming growth factor-beta (TGF-beta) and prostaglandins (PG) regulate the cell-mediated immune response, so it has been proposed that they affect the progression of pulmonary tuberculosis. Here we report that the administration of soluble betaglycan, a potent TGF-beta antagonist, and niflumic acid, a PG synthesis inhibitor, during the chronic phase of experimental murine tuberculosis enhanced Th1 and decreased Th2 cytokines, increased the expression of iNOS and reduced pulmonary inflammation, fibrosis and bacillary load. This immunotherapeutic approach resulted in significant control of the disease comparable to that achieved by anti-microbial treatment alone. Importantly, the combination of immunotherapy and anti-microbials resulted in an accelerated clearance of bacilli from the lung. These results confirm that TGF-beta and PG have a central pathophysiological role in the progression of pulmonary tuberculosis in the mouse and suggest that the addition of immunotherapy to conventional anti-microbial drugs might result in improved treatment of the disease.

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Citations

Oct 9, 2013·BMC Complementary and Alternative Medicine·Adelina Jiménez-ArellanesRogelio Hernández-Pando
Feb 22, 2012·Immunotherapy·Mercedes Gonzalez-Juarrero
Jul 19, 2013·Seminars in Immunopathology·Evelyn GuiradoGilla Kaplan
Aug 27, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Rogelio Hernandez-PandoDiana Aguilar
Jan 8, 2013·Archives of Medical Research·Rosalba León-DíazMaría Adelina Jiménez-Arellanes
Jan 21, 2016·Tuberculosis·Jesus F Rangel-SantiagoSara Huerta-Yepez
Nov 8, 2011·Infectious Disease Clinics of North America·Vidya SundareshanNancy Misri Khardori
Feb 10, 2009·The Journal of Infectious Diseases·Graham A W RookAlimuddin Zumla
Nov 21, 2009·Clinics in Chest Medicine·Gavin J ChurchyardGraham A Rook
Mar 20, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·R Hernández-PandoD Mata-Espinosa
Mar 27, 2018·Expert Review of Respiratory Medicine·Octavio Ramos-EspinosaRogelio Hernández-Pando
Sep 7, 2006·American Journal of Physiology. Renal Physiology·Patricia JuárezFernando López-Casillas
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lucinda RandPaul T G Elkington
Oct 10, 2018·Frontiers in Cellular and Infection Microbiology·Nelita du PlessisGerhard Walzl
Jun 28, 2019·Frontiers in Endocrinology·Mario ZetterRogelio Hernández-Pando
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Catharine M BosioJohn T Belisle
Feb 28, 2021·Annual Review of Immunology·Mariëtta M Ravesloot-ChávezSarah A Stanley
Jun 8, 2021·Frontiers in Immunology·Daniela E KirwanJon S Friedland
Nov 7, 2020·Journal of Leukocyte Biology·Marthe Jøntvedt JørgensenAnne Ma Dyrhol-Riise

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