A combination of cis-2-decenoic acid and chlorhexidine removes dental plaque

Archives of Oral Biology
Azadeh Rahmani-BadiHamta Babaie-Naiej

Abstract

To investigate the ability of cis-2-decenoic acid (C2DA) to induce dispersion in single-species biofilms formed by Streptococcus mutans and Candida albicans, as well as to remove their bacterial-fungal dual-species biofilms when combined with low concentrations of chlorhexidine (CHX). For biofilm dispersal bioassays, single-species biofilms of S. mutans and C. albicans were grown on the inside surface of petri dishes, using a semi-batch culture method in which the medium was replaced every 24h for 5 days. Biofilms were then treated with very low concentrations of C2DA (100 and 310 nM) for 1h to release cells into the bulk liquid and to evaluate dispersed cell number by measuring the optical density (OD). To assess the ability of C2DA combined CHX treatments to remove tested microorganisms' dual-species biofilms, they were grown on saliva-coated hydroxyapatite (sHA) discs for 48 h and then were treated with three different concentrations of CHX (0.08%, 0.06% and 0.04%) alone or in combination with indicated concentrations of C2DA for 1 min twice daily for 3 subsequent days. Biofilms were then either subjected to the field emission scanning electron microscopy (FESEM) analysis or harvested and colony forming units (CFUs) were cou...Continue Reading

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Citations

Apr 20, 2017·Molecular Microbiology·Cyril GuilhenDamien Balestrino
Apr 4, 2017·Microorganisms·Derek Fleming, Kendra P Rumbaugh
Dec 12, 2017·Medical Mycology·Marlene ChevalierIsabelle Prêcheur
Aug 31, 2019·Drugs·Claudia Vuotto, Gianfranco Donelli
Nov 21, 2019·Medicinal Research Reviews·Miao Yu, Song Lin Chua
May 3, 2019·BMC Oral Health·Abdul Razzak A GhazalRichard D Cannon
Jun 14, 2020·Nature Reviews. Microbiology·Kendra P Rumbaugh, Karin Sauer
Apr 20, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Zoe L HarrisonJ Amber Jennings
May 19, 2021·Critical Reviews in Microbiology·Fazlurrahman KhanYoung-Mog Kim
Jun 29, 2021·Frontiers in Microbiology·Zoe L HarrisonJessica Amber Jennings

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