A combination of histological analyses and uniaxial tensile tests to determine the material coefficients of the healthy and atherosclerotic human coronary arteries
Abstract
Atherosclerosis is considered as the most severe form of cardiovascular diseases as it alters the structure of the elastin and collagen and, consequently, the mechanical properties of the artery wall. The role of collagen fibers orientations in the mechanical properties of the healthy and atherosclerotic human coronary arteries so far has not been well determined. In this study, a fiber family based constitutive equation was employed to address the mechanical behavior of healthy and atherosclerotic human coronary arteries using the combination of histostructural and uniaxial data. A group of six healthy and atherosclerotic human coronary arteries was excised at autopsy and histological analyses were performed on each artery to determine the mean angle of collagen fibers. The preconditioned arterial tissues were then subjected to a series of quasi-static axial and circumferential loadings. The key role of fiber orientation was explicitly added into a proposed strain energy density function. The constrained nonlinear optimization method was used to determine the material coefficients based on the axial and circumferential extension data of the arteries. The material coefficients of coronary arteries were given with R(2)≥0.991. Th...Continue Reading
References
Citations
Mechanical characterization of the rat and mice skin tissues using histostructural and uniaxial data
Related Concepts
Related Feeds
Cardiovascular Disease Pathophysiology
Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.