A combination of histological analyses and uniaxial tensile tests to determine the material coefficients of the healthy and atherosclerotic human coronary arteries

Tissue & Cell
Alireza KarimiAhmad Shojaei

Abstract

Atherosclerosis is considered as the most severe form of cardiovascular diseases as it alters the structure of the elastin and collagen and, consequently, the mechanical properties of the artery wall. The role of collagen fibers orientations in the mechanical properties of the healthy and atherosclerotic human coronary arteries so far has not been well determined. In this study, a fiber family based constitutive equation was employed to address the mechanical behavior of healthy and atherosclerotic human coronary arteries using the combination of histostructural and uniaxial data. A group of six healthy and atherosclerotic human coronary arteries was excised at autopsy and histological analyses were performed on each artery to determine the mean angle of collagen fibers. The preconditioned arterial tissues were then subjected to a series of quasi-static axial and circumferential loadings. The key role of fiber orientation was explicitly added into a proposed strain energy density function. The constrained nonlinear optimization method was used to determine the material coefficients based on the axial and circumferential extension data of the arteries. The material coefficients of coronary arteries were given with R(2)≥0.991. Th...Continue Reading

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Apr 8, 2014·Biomedizinische Technik. Biomedical Engineering·Alireza KarimiReza Razaghi
Jul 6, 2014·Biomedizinische Technik. Biomedical Engineering·Alireza Karimi, Mahdi Navidbakhsh
Jul 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Alireza KarimiReza Razaghi
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Citations

Sep 12, 2015·Journal of Medical Engineering & Technology·Alireza KarimiSusumu Kudo
Oct 16, 2015·Australasian Physical & Engineering Sciences in Medicine·Farshid RezaeiAlireza Karimi
Aug 19, 2017·Journal of Materials Science. Materials in Medicine·Arezoo KhosraviAlireza Karimi
Nov 14, 2017·Digestive Diseases·Alireza Karimi, Ahmad Shojaei
Apr 13, 2018·Frontiers in Physiology·Gonzalo D Maso TalouRaúl A Feijóo
Aug 15, 2018·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Alireza Karimi, Reza Razaghi

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