A combination of keratan sulfate digestion and rehabilitation promotes anatomical plasticity after rat spinal cord injury

Neuroscience Letters
Yoshimoto IshikawaKenji Kadomatsu

Abstract

Functional recovery after neuronal injuries relies on neuronal network reconstruction which involves many repair processes, such as sealing of injured axon ends, axon regeneration/sprouting, and construction and refinement of synaptic connections. Chondroitin sulfate (CS) is a major inhibitor of axon regeneration/sprouting. It has been reported that the combination of task-specific rehabilitation and CS-digestion is much more effective than either treatment alone with regard to the promotion of functional and anatomical plasticity for dexterity in acute and chronic spinal cord injury models. We previously reported that keratan sulfate (KS) is another inhibitor and has a potency equal to CS. Here, we compared the effects of KS- or CS-digestion plus rehabilitation on recovery from spinal cord injury. Keratanase II or chondroitinase ABC was locally administered at the lesion after spinal cord injury at C3/4. Task-specific rehabilitation training, i.e., a single pellet reaching task using a Whishaw apparatus, was done for 3 weeks before injury, and then again at 1-6 weeks after injury. The combination of KS-digestion and rehabilitation yielded a better rate of pellet removal than either KS-digestion alone or rehabilitation alone, a...Continue Reading

References

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Citations

Aug 19, 2015·Experimental Neurology·Patrice D SmithJames W Fawcett
Aug 4, 2018·Journal of Neurotrauma·Abel Torres-EspínKarim Fouad
Jan 19, 2018·Journal of Neuroscience Research·Naijil George, Herbert M Geller
Aug 18, 2018·The Biochemical Journal·Anthony J Hayes, James Melrose
Dec 24, 2020·Journal of Neurotrauma·Leslie R MorseUNKNOWN SCI 2020 Working Group

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