A combination of platelet features allows detection of early-stage cancer

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Siamack SabrkhanyMirjam G A Oude Egbrink

Abstract

Detection of early-stage cancer significantly improves patient survival. As platelets play an important role in cancer progression, we aimed to investigate whether platelets can be used for the discovery of early-stage cancer. Patients with lung (n = 86) or head of pancreas (n = 42) cancer were included, as were healthy sex- and age-matched controls (n = 92). Blood was collected before initiation of treatment. Platelet count, volume and activation status were quantified in whole blood. Next, concentrations of vascular endothelial growth factor, platelet-derived growth factor, platelet factor 4, thrombospondin-1 and connective tissue-activating peptide III were measured in both platelets and plasma. Using the results, two multivariable diagnostic models were developed and internally validated. Multiple platelet features, including platelet count, volume and protein content, were significantly changed in lung and head of pancreas cancer patients. However, the pattern of changes differed between both groups. The diagnostic model developed for lung cancer discriminated very well between patients and controls (AUC = 88.7%). Addition of smoking as a variable significantly increased the AUC of the model to 94.5%. The diagnostic model ...Continue Reading

Citations

Jul 6, 2018·Journal of Thrombosis and Haemostasis : JTH·B M E TullemansM J E Kuijpers
Nov 15, 2018·Journal of Surgical Oncology·Ferdinando Carlo Maria CananziVittorio Lorenzo Quagliuolo
Oct 21, 2018·Angiogenesis·Siamack SabrkhanyMirjam G A Oude Egbrink
Mar 16, 2019·Technology in Cancer Research & Treatment·Jing-Jing WangWei Li
Mar 6, 2019·Blood·Sjors G J G In 't Veld, Thomas Wurdinger
Dec 22, 2019·Cancers·Erika RijavecFrancesco Grossi
May 29, 2020·Biomarkers in Medicine·Tanya N Augustine
Nov 22, 2020·Molecular Oncology·Mafalda Antunes-FerreiraThomas Würdinger
Feb 27, 2021·Cancer Metastasis Reviews·Siamack SabrkhanyArjan W Griffioen
May 4, 2021·Blood·Harvey G Roweth, Elisabeth M Battinelli
Jun 16, 2021·Thrombosis and Haemostasis·Bibian M E TullemansMarijke J E Kuijpers
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Dec 4, 2021·Frontiers in Cell and Developmental Biology·Shaoshan Mai, Iwona Inkielewicz-Stepniak

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