A combination of serum iron, ferritin and transferrin predicts outcome in patients with intracerebral hemorrhage

Scientific Reports
Guang YangZhong-Ming Qian

Abstract

Association of a high-serum ferritin with poor outcome showed that iron might play a detrimental role in the brain after intracerebral hemorrhage (ICH). Here, we investigated changes in serum iron, ferritin, transferrin (Tf) and ceruloplasmin (CP) in patients with ICH (n = 100) at day 1 (admission), 3, 7, 14 and 21 and those in control subjects (n = 75). The hematoma and edema volumes were also determined in ICH-patients on admission and at day 3. The Modified Rankin Scale (mRS) of 59 patients was ≥3 (poor outcome) and 41 < 3 (good outcome) at day 90. Serum ferritin was significantly higher and serum iron and Tf markedly lower in patients with poor-outcome than the corresponding values in patients with good-outcome at day 1 to 7 and those in the controls. There was a significant positive correlation between serum ferritin and relative edema volume or ratio at day 1 and 3 and hematoma volume at day 1 (n = 28), and a negative correlation between serum iron or Tf and hematoma volume at day 1 (n = 100). We concluded that not only increased serum ferritin but also reduced serum iron and Tf are associated with outcome as well as hematoma volume.

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Citations

Nov 20, 2018·Brain and Behavior·Ling XieShengnan Wang
Jun 8, 2017·Frontiers in Physiology·Yu-Fu ZhouYa Ke
Sep 30, 2017·Stroke and Vascular Neurology·Thomas GartonGuohua Xi
Oct 17, 2019·Molecular Neurobiology·Steven A RobicsekSylvain Doré
Aug 19, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Takahiko ImaiMasamitsu Shimazawa
Jan 15, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takahiko ImaiHideaki Hara
Sep 16, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Guang YangZhong-Ming Qian
Jan 11, 2021·Molecular and Cellular Neurosciences·Chao ZhangZhong-Ming Qian
May 4, 2021·Neurological Research and Practice·Jens WitschHagen B Huttner
Jan 13, 2022·Neural Regeneration Research·Daniyah A AlmarghalaniZahoor A Shah

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Methods Mentioned

BETA
blood drawn

Clinical Trials Mentioned

NCT02135783

Software Mentioned

SPSS
Cons
Surg

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