A combination of simvastatin and methylprednisolone improves the quality of vitrified-warmed ovarian tissue after auto-transplantation

Human Reproduction
Jaewang LeeSeok Hyun Kim

Abstract

Does the preoperative administration of simvastatin and methylprednisolone enhance mouse ovarian quality after auto-transplantation of vitrified-warmed ovarian tissue (OT)? Treatment with combined simvastatin and methylprednisolone enhances the quality of transplanted mouse OTs. The prevention of ischemic injury after transplantation of OT is critical for preserving the ovarian follicles. Preoperative administration of simvastatin (a cholesterol-lowering drug) has beneficial effects on various organ transplantations. Moreover, donor treatment with simvastatin and methylprednisolone (main effects are on immune response) prevents ischemia-reperfusion injury and has a beneficial effect on allograft survival in rat cardiac allografts. A total of 232 6-week-old B6D2F1 mice were randomly distributed into fresh control, vitrified-warmed control and experimental groups (n = 10-17 per group). The experimental groups were as follows: sham control, simvastatin, methylprednisolone and co-treatment groups. In the experimental groups, the mice were administered simvastatin (5 mg/kg, orally), methylprednisolone (15 mg/kg, i.v.) or a combination of simvastatin and methylprednisolone 2 h before ovariectomy, whereas the sham control mice receive...Continue Reading

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Citations

Mar 28, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Benjamin Fisch, Ronit Abir
May 21, 2020·Journal of Assisted Reproduction and Genetics·Shichen ZhangYanfeng Wang
Jan 23, 2018·Journal of Assisted Reproduction and Genetics·Naoki OkamotoNao Suzuki
Jul 28, 2020·Journal of Assisted Reproduction and Genetics·Ronit AbirYoel Shufaro
Feb 19, 2021·Computational and Structural Biotechnology Journal·Seo-Ree ChoiJoon-Hwa Lee
Apr 11, 2021·Reproductive Biology and Endocrinology : RB&E·Dalin WangYanqiu Hu

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