PMID: 9649013Jul 2, 1998Paper

A combination therapy with simvastatin and ursodeoxycholic acid is more effective for cholesterol gallstone dissolution than is ursodeoxycholic acid monotherapy

Journal of Clinical Gastroenterology
Susumu TazumaS Kokubu

Abstract

Inhibitors of 3-hydroxy,3-methylglutaryl coenzyme A (HMG-CoA) reductase have been reported to decrease the cholesterol saturation index (CSI) in duodenal bile in humans and to prevent formation of cholesterol gallstones in animal studies. We performed a prospective study to evaluate the role of HMG-CoA reductase inhibitors as gallstone-dissolving agents. Fifty patients with radiolucent gallstones in a gallbladder opacifying at drip infusion cholecystography were treated with either 10 mg/day simvastatin plus 600 mg/day ursodeoxycholic acid (group 1, n=26) or 600 mg/day ursodeoxycholic acid alone (group 2, n=24) for 12 months. The ratio of solitary to multiple gallstone cases was 21:29. Plasma lipid levels were assessed and ultrasonographic examination of the gallbladder was performed at baseline and at 3-month intervals during treatment. Duodenal bile sampling was performed in five patients in each group at baseline and after 12 months of treatment. Plasma cholesterol decreased significantly in group 1 but not in group 2. In solitary gallstone cases, no significant difference in dissolution rates was observed between groups 1 (3 of 9, 33%) and 2 (4 of 12, 33%). In contrast, the dissolution rate in multiple gallstone cases was s...Continue Reading

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Citations

Oct 18, 2011·BMC Gastroenterology·Shih-Chang HungWen-Chi Chen
Oct 25, 2011·PloS One·Rima Kaddurah-DaoukRonald M Krauss
May 21, 2010·Expert Opinion on Drug Safety·Eugene MerzonShlomo Vinker
Feb 12, 2009·Gastroenterology·Chung-Jyi TsaiEdward L Giovannucci
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Jan 25, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Piero Portincasa, David Q-H Wang
Aug 19, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Nobusuke KishikawaSusumu Tazuma
Oct 16, 2001·Drugs & Aging·B TomlinsonW Lan
Mar 22, 2014·Scandinavian Journal of Gastroenterology·Mohamed H Ahmed, Asif Ali
Dec 13, 2016·Journal of Gastroenterology·Susumu TazumaTooru Shimosegawa
Oct 7, 2006·Current Opinion in Gastroenterology·W A Hoogerwerf, R D Soloway
Apr 4, 2021·Cancers·Kritika PrasaiAmit Mahipal

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