A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold

Chemical Communications : Chem Comm
Gwenn E MulderRob M J Liskamp

Abstract

We describe rapid and convenient access to smart libraries of protein surface discontinuous epitope mimics. Up to three different cyclic peptides, representing discontinuous epitopes in HIV-gp120, were conjugated to a triazacyclophane scaffold molecule via CuAAC. In this way protein mimics for use as synthetic vaccines and beyond will become available.

References

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Citations

Jun 8, 2013·Amino Acids·Alessandro GoriGiorgio Colombo
Apr 12, 2013·ACS Combinatorial Science·Miriam Góngora-BenítezFernando Albericio
Mar 13, 2014·The Journal of Organic Chemistry·Xavier ElduqueAnna Grandas
Dec 17, 2016·Chembiochem : a European Journal of Chemical Biology·Helmus van de LangemheenRob M J Liskamp
May 23, 2014·Organic & Biomolecular Chemistry·Helmus van de LangemheenRob M J Liskamp
Mar 8, 2013·Organic & Biomolecular Chemistry·Gwenn E MulderRob M J Liskamp
Sep 30, 2014·Organic & Biomolecular Chemistry·M Angeles BonacheRosario González-Muñiz

Related Concepts

Antigenic Specificity
HIV
Cyclic Peptides
HIV Envelope Protein gp120
Small Molecule Libraries
Epitopes
HIV Infections
Cyclic Peptides
Vaccines
Surface

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