A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold

Chemical Communications : Chem Comm
Gwenn E MulderRob M J Liskamp


We describe rapid and convenient access to smart libraries of protein surface discontinuous epitope mimics. Up to three different cyclic peptides, representing discontinuous epitopes in HIV-gp120, were conjugated to a triazacyclophane scaffold molecule via CuAAC. In this way protein mimics for use as synthetic vaccines and beyond will become available.


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Related Concepts

Antigenic Specificity
Cyclic Peptides
HIV Envelope Protein gp120
Small Molecule Libraries
HIV Infections
Cyclic Peptides

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