A Combinatorial Lipid Code Shapes the Electrostatic Landscape of Plant Endomembranes

Developmental Cell
Matthieu Pierre PlatreYvon Jaillais

Abstract

Membrane surface charge is critical for the transient, yet specific recruitment of proteins with polybasic regions to certain organelles. In eukaryotes, the plasma membrane (PM) is the most electronegative compartment of the cell, which specifies its identity. As such, membrane electrostatics is a central parameter in signaling, intracellular trafficking, and polarity. Here, we explore which are the lipids that control membrane electrostatics using plants as a model. We show that phosphatidylinositol-4-phosphate (PI4P), phosphatidic acidic (PA), and phosphatidylserine (PS) are separately required to generate the electrostatic signature of the plant PM. In addition, we reveal the existence of an electrostatic territory that is organized as a gradient along the endocytic pathway and is controlled by PS/PI4P combination. Altogether, we propose that combinatorial lipid composition of the cytosolic leaflet of organelles not only defines the electrostatic territory but also distinguishes different functional compartments within this territory by specifying their varying surface charges.

Citations

Jun 28, 2018·Molecular Biology of the Cell·Mengxiao MaChristopher G Burd
Feb 5, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·František Baluška, Arthur Reber
Jun 24, 2019·The New Phytologist·Liang ZhangJinxing Lin
Feb 18, 2020·The Plant Journal : for Cell and Molecular Biology·Přemysl PejcharMartin Potocký
Apr 17, 2020·Plants·Frank Ackermann, Thomas Stanislas
May 23, 2020·Annual Review of Plant Biology·Lise C Noack, Yvon Jaillais
Aug 7, 2019·International Journal of Molecular Sciences·Zdeňka KubátováIvan Kulich
Jun 24, 2020·Biochemistry. Biokhimii︠a︡·A V PankratenkoA G Solovyev
Jul 18, 2020·Frontiers in Plant Science·Tamara PečenkováFatima Cvrčková
May 22, 2019·Frontiers in Plant Science·Marie-Cécile Caillaud
Mar 9, 2019·Frontiers in Plant Science·Jules D PetitEmmanuelle M Bayer
Aug 24, 2019·Progress in Lipid Research·Yasuhiro Higashi, Kazuki Saito
Dec 24, 2019·Developmental Cell·Petra MarhavaChristian S Hardtke
Feb 28, 2021·Science Advances·Klaas YpermanRoman Pleskot
Mar 7, 2020·Current Opinion in Cell Biology·Laura L Thomas, J Christopher Fromme
Feb 24, 2021·Comptes rendus biologies·Matthieu Pierre Platre
Apr 7, 2021·Plant Physiology·Rosa L López-MarquésMichael Palmgren
Apr 2, 2021·Plant Physiology·Gwennogan A Dubois, Yvon Jaillais
Apr 2, 2021·Plant Physiology·Marija SmokvarskaAlexandre Martinière
Nov 23, 2018·Progress in Lipid Research·Adiilah Mamode CassimSébastien Mongrand
May 20, 2021·Nature Plants·Mehdi DoumaneMarie-Cécile Caillaud
May 26, 2021·Nature Communications·Klaas YpermanDaniel Van Damme
Jul 30, 2021·The Journal of Cell Biology·Laurine M GillesThomas Widiez
Aug 3, 2021·The Plant Cell·João Jacob RamalhoDolf Weijers
Aug 27, 2021·Membranes·Miliça RistovskiJyh-Yeuan Lee
Aug 28, 2021·International Journal of Molecular Sciences·Yoko ItoYohann Boutté
Sep 3, 2021·Proceedings of the National Academy of Sciences of the United States of America·Lukáš SynekMartin Potocký
Sep 23, 2021·The Plant Cell·Fernando AnientoEugenia Russinova
Sep 30, 2021·The Plant Cell·Leia ColinYvon Jaillais
Nov 15, 2021·The FEBS Journal·Anna BoccaccioJoachim Scholz-Starke
Oct 12, 2021·The Plant Cell·Byung-Ho KangBethany Karlin Zolman
Jan 5, 2022·Journal of Experimental Botany·Valérie Wattelet-BoyerPatrick Moreau
Dec 22, 2021·The New Phytologist·Patricia ScholzTill Ischebeck

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.