PMID: 8591703Aug 1, 1995Paper

A combined casein-free-nicotinamide diet prevents diabetes in the NOD mouse with minimum insulitis

Diabetes Research and Clinical Practice
S ReddyR B Elliott

Abstract

We have previously shown that diabetes in the NOD mouse can be prevented if mice are placed from weaning on an infant formula diet in which the protein source is replaced with casein hydrolysate (Pregestimil) or soy protein (Prosobee), or if 1% nicotinamide is given in the drinking water. Nicotinamide somewhat suppresses insulitis but the hydrolysed casein formula does not. In this study, Prosobee was given concurrently with oral nicotinamide from weaning and their effects on the development of insulitis and diabetes measured. These effects were also assessed in mice given Prosobee alone from conception (day -20) or from weaning. Unlike the earlier experiments, a marked suppression of insulitis was observed when the diets and nicotinamide were given concurrently (mean insulitis scores +95% confidence intervals (back transformed): day 40 = 0.4% [0.03, 1.17] vs. 12.5% [2.52, 28.40] and at day 90 = 8.8% [3.65, 15.68] vs. 48.1% [33.89, 62.49], P = 0.0001). A similar suppression was observed on day 90 with Pregestimil combined with nicotinamide 7.3% [3.88, 11.70] vs. 43.8% [32.59, 55.35] (P = 0.0001). Qualitatively, introduction of Prosobee from conception appeared to elicit a greater degree of suppression of insulitis than when int...Continue Reading

References

Nov 1, 1991·Diabetes Care·K Dahl-JørgensenK F Hanssen
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·Z J ZhangH L Weiner
Mar 29, 1991·Biochemical and Biophysical Research Communications·K D KrönckeH Kolb
Apr 1, 1990·Diabetes·D L ColemanE H Leiter
May 19, 1990·BMJ : British Medical Journal·G G DahlquistS G Wall
Mar 15, 1988·Experientia·D Migliore-Samour, P Jollès
Sep 1, 1993·The Journal of Clinical Investigation·T OtonkoskiA Hayek

❮ Previous
Next ❯

Citations

Sep 29, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kenneth MaieseYan Chen Shang
Nov 3, 2007·Neurochemistry International·Dan JiNeville N Osborne
Jun 7, 2007·Pediatric Diabetes·UNKNOWN TRIGR Study Group
Mar 12, 2010·Journal of Clinical Pharmacology·Kenneth MaieseJinling Hou
Aug 25, 2010·Journal of Cellular and Molecular Medicine·Andriy SukhodubAleksandar Jovanović
Mar 18, 2006·Endocrine Journal·Takeshi Usui
Nov 7, 1999·Journal of Autoimmunity·E SarugeriE Bonifacio
Aug 30, 2018·Human Vaccines & Immunotherapeutics·James A PearsonLi Wen
Feb 23, 2008·International Journal of Toxicology·M D NemecD E Strother
Nov 25, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·P PozzilliA Picardi
Dec 10, 1999·Diabetes/metabolism Research and Reviews·D P FundaK Buschard
Nov 27, 2002·The American Journal of Clinical Nutrition·Sam J Bhathena, Manuel T Velasquez
Mar 18, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kenneth Maiese

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.