A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia

Neuroscience Letters
Haiying ZhangYan Shen

Abstract

Recent studies suggest that both the KPNB3 gene and the KPNA3 gene in the long arm of chromosome 13 (13q) are associated with schizophrenia. Because these two genes belong to the same family of karyopherins, their combined effect on illness was investigated among 238 Chinese family trios consisting of fathers, mothers and affected offspring with schizophrenia. We detected three single nucleotide polymorphisms (SNPs), including rs626716 at the KPNB3 locus, and rs3782929 and rs3736830 at the KPNA3 locus. The transmission disequilibrium test (TDT) showed allelic association for rs626716 (X2=10.77, P=0.001) and for rs3782929 (X2=4.89, P=0.027) but not for rs3736830 (X2=0.29, P=0.59). Although the conditional test did not show association either for the rs626716-rs3782929 combinations (X2=1.329, d.f.=2, P=0.514) or for the rs626716-rs3736830 combinations (X2=0.606, d.f.=2, P=0.739), the 1-d.f. test showed association for the rs626716(C)-rs3782929(G) combination (X2=10.79, P=0.001) and for the rs626716(C)-rs3736830(G) combination (X2=8.64, P=0.003). The present work suggests that the combination of the KPNA3 gene and the KPNB3 gene may increase a genetic risk for schizophrenia.

References

Jan 5, 2000·Cell·S Nakielny, G Dreyfuss
Aug 14, 2003·Genetic Epidemiology·Frank Dudbridge
Sep 15, 2004·Neuroscience Letters·Jun Wei, Gwynneth P Hemmings
May 11, 2005·Neuroscience Research·Jun Wei, Gwynneth P Hemmings

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Citations

Oct 11, 2007·Molecular Psychiatry·G KaroutzouD E Dietrich
Jun 26, 2012·Nucleic Acids Research·Hsu-Wen ChaoYi-Shuian Huang
Jan 5, 2012·Molecular Cytogenetics·Sharon L GrawSherry Leonard
May 5, 2009·Seminars in Cell & Developmental Biology·Rotem Ben-Tov Perry, Mike Fainzilber
Feb 7, 2015·The Biochemical Journal·Ruth A Pumroy, Gino Cingolani

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