A combined epigenetic therapy equals the efficacy of conventional chemotherapy in refractory advanced non-small cell lung cancer

Cancer Discovery
Manuel Rodríguez-Paredes, Manel Esteller

Abstract

A new study by Juergens and colleagues provides the first successful example of a combined epigenetic therapy capable of achieving results similar to those of conventional chemotherapy in refractory metastatic non-small cell lung cancer. Furthermore, the authors describe interesting blood-based DNA methylation biomarkers that may be useful in predicting clinical response.

References

Nov 9, 2000·The New England Journal of Medicine·M EstellerJ G Herman
Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp
Mar 14, 2008·The New England Journal of Medicine·Malcolm V BrockJames G Herman
Mar 10, 2011·Nature Medicine·Manuel Rodríguez-Paredes, Manel Esteller
Apr 13, 2011·Genes, Chromosomes & Cancer·Laia Simó-RiudalbasManel Esteller

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Citations

Feb 27, 2014·Biotechnology & Genetic Engineering Reviews·C Patrick McAtee
Mar 13, 2014·ChemMedChem·Nadeem A Vellore, Riccardo Baron
Jul 6, 2016·EMBO Molecular Medicine·Mélodie GrandinRobert Dante
Apr 1, 2020·International Journal of Molecular Sciences·Mehdi MoustaqilEmma Sierecki

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