PMID: 375079Feb 1, 1979Paper

A combined testing protocol approach for mutagenicity testing

Mutation Research
T H ConnorM S Legator

Abstract

The antischistosomal agent, hycanthone methanesulfonate (HMS), was employed to illustrate the utility of carrying out several mutagenicity tests in a single concurrent animal experiment. Several commonly used procedures that were successfully integrated into a multiple testing protocol included (1) metaphase analysis in bone marrow, (2) micronucleus test in bone marrow, (3) analysis of the urine for mutagenic constituents, and (4) the host-mediated assay using Salmonella typhimurium. In addition to these animal studies, in vitro mutagenicity testing with and without activation was carried out using S. typhimurium. HMS produced positive, dose--response effects in in vitro tests, metaphase analysis, micronucleus test, and urine analysis, but not in the host-mediated assay. The results of these integrated techniques suggest that such a protocol may be a benefit to those concerned with mutagenicity testing of chemicals.

References

Feb 1, 1975·Mutation Research·W Schmid
Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·R H San, H F Stich
Nov 1, 1975·Journal of Toxicology and Environmental Health·S M Sieber, R H Adamson
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·W E Durston, B N Ames
Sep 8, 1972·Nature·J A Moore
Jun 1, 1973·Agents and Actions·W W Nichols
Jun 4, 1971·Science·P E HartmanH Berger
Oct 15, 1958·Proceedings of the National Academy of Sciences of the United States of America·J Spizizen

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Citations

Jan 1, 1982·International Archives of Occupational and Environmental Health·R PasquiniF Fagioli
Mar 1, 1985·Mutation Research·J C HeussnerM S Legator
May 1, 1988·Mutation Research·W W AuM S Legator
Jan 1, 1988·Annals of the New York Academy of Sciences·M S Legator, B L Harper
Jan 1, 1985·American Journal of Industrial Medicine·M M Gad-el-KarimM S Legator

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