A combined treatment of curcumin, piperine, and taurine alters the circulating levels of IL-10 and miR-21 in hepatocellular carcinoma patients: a pilot study

Journal of Gastrointestinal Oncology
Hala M HatabMotawa E El-Houseini

Abstract

Investigating and evaluating possible alternative therapeutic strategies to control hepatocellular carcinoma (HCC) is a critical need because of its high prevalence and being one of the most lethal cancers. Curcumin and taurine showed potent anti-tumor activities in pre-clinical and clinical studies by targeting multiple pathways. Thus, this study was designed to assess the effect of a combined treatment consisted of curcumin, piperine, and taurine on circulating levels of interleukin-10 (IL-10), and microRNAs miR-141 and miR-21. Twenty eligible HCC patients administrated an oral dose of 4 g curcumin, 40 mg piperine, and 500 mg taurine daily for three successive treatment cycles, each was a 30-day. The level of IL-10 along with the expression levels of miR-141, and miR-21 were monitored in serum before starting the treatment and after each cycle. Patients were followed-up for a period of 24 months. The combined treatment was able to produce a significant decrease in the levels of serum IL-10, and miR-21 while it resulted in a non-significant up-regulation of serum miR-141 expression level. At the end of the follow-up period, the median overall survival (OS) rate was found to be 17.00 months with a worse OS in patients with high...Continue Reading

Citations

Sep 16, 2020·Phytotherapy Research : PTR·Iahtisham-Ul HaqMohammad S Mubarak
Jun 26, 2020·Frontiers in Immunology·Zhonghua ZhengShiwei Duan
Nov 27, 2020·The Journal of International Medical Research·Hai-Bo Zou, Xiao-Feng Sun
Jun 27, 2021·Phytotherapy Research : PTR·Korosh MorshediHamed Mirzaei
Jul 30, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Beilei ZhangFu Wang

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