A comitogenic serum glycoprotein in T lymphocyte activation

Immunobiology
H A FabriciusG W Löhr

Abstract

The production of Interleukin-2 is induced in helper cells, probably of T-cell origin, after stimulation by Interleukin-1. PHA is known to induce production of Interleukin-1 and Interleukin-2 in human PBL. We observed that PHA-induced mitogenesis in PBL requires the presence of a 90-KD-serum glycoprotein, which we were able to distinguish from other known serum proteins of similar molecular weight. Its biological activity can be destroyed by removal of its sialic acid residues. Evidence presented in this paper indicates that the function of this protein is related to the induction of synthesis and/or release of Interleukin-2. The presence of PHA does not seem to be essential at the level of Interleukin-2 production; the glycoprotein is able to induce Interleukin-2 in cooperation with a soluble mediator, which is produced by adherent cells. This mediator causes T-cell mitogenesis in PBL, provided serum or the 90-KD glycoprotein is present in the culture. It is not able to support the growth of a CTL line. We suggest the name PHILIP (Plasmatic Human Interleukin-2-Inducing Protein) for the 90-KD molecule.

References

Oct 1, 1978·The Journal of Experimental Medicine·S GillisK A Smith
Jul 19, 1979·Nature·E L Larsson, A Coutinho
Dec 1, 1979·European Journal of Immunology·M L Dillner-CenterlindP Perlmann
Jan 1, 1972·Transplantation Reviews·M Greaves, G Janossy
Jul 1, 1970·The Journal of Experimental Medicine·R C Seeger, J J Oppenheim
Nov 1, 1981·Cellular Immunology·M PiantelliP Musiani
Dec 1, 1980·Immunology Today·J WatsonS Gillis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.