A comment on the analysis of bell-shaped dose-response curves

The Japanese Journal of Physiology
M Kasai

Abstract

A problem of the analysis of bell-shaped dose-response curves was theoretically discussed by using the response of ryanodine receptors for Ca2+ concentration as a model case. Usually the response curves were analyzed under the assumption that the receptor has a high affinity activation site and a low affinity inhibition site. However, a solution having a low affinity activation site and a high affinity inhibition site can be deduced theoretically from the same data. A method to avoid an erroneous result was proposed.

Citations

Jun 5, 2010·Biological & Pharmaceutical Bulletin·Tae Ho LeeSun Yeou Kim
Jun 27, 2012·European Journal of Pharmacology·Maegan M WeltzinMarvin K Schulte
Mar 16, 2007·American Journal of Physiology. Cell Physiology·Ricardo BullCecilia Hidalgo

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