A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice

Science Translational Medicine
Haixia YangGuodong Zhang

Abstract

Triclosan (TCS) is a high-volume chemical used as an antimicrobial ingredient in more than 2000 consumer products, such as toothpaste, cosmetics, kitchenware, and toys. We report that brief exposure to TCS, at relatively low doses, causes low-grade colonic inflammation, increases colitis, and exacerbates colitis-associated colon cancer in mice. Exposure to TCS alters gut microbiota in mice, and its proinflammatory effect is attenuated in germ-free mice. In addition, TCS treatment increases activation of Toll-like receptor 4 (TLR4) signaling in vivo and fails to promote colitis in Tlr4-/- mice. Together, our results demonstrate that this widely used antimicrobial ingredient could have adverse effects on colonic inflammation and associated colon tumorigenesis through modulation of the gut microbiota and TLR4 signaling. Together, these results highlight the need to reassess the effects of TCS on human health and potentially update policies regulating the use of this widely used antimicrobial.

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Citations

Nov 15, 2018·DNA and Cell Biology·Haixia YangGuodong Zhang
Oct 5, 2019·Nutrients·Federica LaudisiGiovanni Monteleone
Dec 24, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Minhao XieGuodong Zhang
Mar 19, 2020·The British Journal of Surgery·Q Denost
Nov 21, 2018·Gut Microbes·Katherine Z SanidadGuodong Zhang
Jun 14, 2019·Oxidative Medicine and Cellular Longevity·Mohammad A Alfhili, Myon-Hee Lee
Sep 22, 2020·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Prabin ShresthaTit-Yee Wong
Jun 27, 2019·BMJ : British Medical Journal·John D Potter
Feb 20, 2019·Scientific Reports·Sandra M W van de WielStan F J van de Graaf
Nov 16, 2019·Molecular Nutrition & Food Research·Haider Rasheed AlrafasPrakash S Nagarkatti
May 7, 2020·Frontiers in Pharmacology·Nehal Adel AbdelsalamRamy Karam Aziz
Jun 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ling ZouPeter J Turnbaugh
Dec 12, 2018·Frontiers in Molecular Neuroscience·Alejandra Arias-CavieresGenaro Barrientos
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Sep 7, 2020·Pharmacology & Therapeutics·Anna FishbeinDipak Panigrahy
Mar 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia-Yi XuFang-Qin Fei
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Jul 13, 2021·Signal Transduction and Targeted Therapy·Huakan ZhaoYongsheng Li
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Sep 14, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rachel BaurStacey E Anderson
Oct 30, 2021·Frontiers in Microbiology·Ning TangFengxiu Ouyang
Nov 7, 2021·Environmental Science and Pollution Research International·Maja MilanovićNataša Milić
Feb 3, 2022·Reviews in Endocrine & Metabolic Disorders·Oren Contreras-RodriguezRosa M Escorihuela

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